Aim: This study aimed to: (a) assess the relationships between climbing performance and finger and shoulder girdle muscle endurance; and (b) provide evidence on the validity of the specialized exercise tests used for the purpose.
Materials And Methods: 28 male sport climbers (climbing ability 23 ± 2.43 IRCRA scale) performed four tests muscle failure, including two-finger hang tests (using 2.5 and 4 cm holds) and two variants of pull-up exercises (classical pull-ups and a combination of dynamic and isometric actions - the so-called Edlinger). Climbing performance and test results were subjected to correlation, taxonomic and regression analysis.
Results: The correlations between the results from all tests and climbing performance were notably strong ( between 0.54 and 0.61) and statistically significant ( ). The taxonomic analysis indicated that the two variants of each test type reflect two different latent variables 2.5 cm and 4 cm finger hang durations were highly correlated ( ). A similar correlation was found between the results from the pull-up tests ( ). Thus, the finger hang and pull-up test results were determined to a high extent (43% and 49%, respectively) by factors that cannot be assessed when only one test of each type is used. The regression model of the two-finger tests allowed individual endurance profiles to be assessed.
Conclusions: The muscular endurance of the elbow flexors and shoulder girdle muscles predicts climbing performance within the specific sport level studied to a comparable degree as finger flexor endurance.The use of two variants of a test intended to assess one physical ability provided important details on a climber's fitness.
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http://dx.doi.org/10.3389/fspor.2024.1410636 | DOI Listing |
Naunyn Schmiedebergs Arch Pharmacol
January 2025
Anhui Provincial Center of Drug Clinical Evaluation, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui, People's Republic of China.
Topiramate is an antiepileptic drug (AED) that is effective in treating various types of epilepsy. This study evaluated the bioequivalence and safety of two topiramate tablets in healthy Chinese subjects under fasting and fed conditions. We designed an open-label, randomized, single-dose, two-period, crossover trial protocol.
View Article and Find Full Text PDFClin Biomech (Bristol)
January 2025
Department for Health, University of Bath, Bath, UK; Centre for the Analysis of Motion, Entertainment Research and Applications (CAMERA), University of Bath, Bath, UK.
Background: Knee loading is associated with the severity and progression of knee osteoarthritis, while knee pain contributes to reduced functional ability and quality of life. In this systematic review, we quantified knee loading and knee pain during different daily activities in people with knee osteoarthritis and explored methodological reasons for differences between studies.
Methods: PubMed, Web of Science, Scopus, and manual searches were performed up to July 2024, to retrieve studies measuring knee loading and knee pain in walking, sit-to-stand and stair climbing of people with knee osteoarthritis.
J Evol Biol
January 2025
Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals de la Universitat de Barcelona (BEECA), Institut de Recerca de la Biodiversitat (IRBio), Universitat de Barcelona.
Differences in habitat use impose ecological constraints which in turn lead to functional and morphological differences through adaptation. In fact, a convergent evolutionary pattern is evident when species exhibit similar responses to similar environments. In this study we examine how habitat use influences the evolution of body shape in lizards from the family Lacertidae.
View Article and Find Full Text PDFJ Clin Hypertens (Greenwich)
January 2025
Department of Cardiology, Hypertension Research Laboratory, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Limited research has investigated the impact of antihypertensive medications on type 2 diabetes mellitus (T2DM) and whether gut microbiome (GM) mediates this association. Thus, we conducted a two-sample Mendelian randomization (MR) analysis to estimate the potential impact of various antihypertensive drug target genes on T2DM and its complications. Genetic instruments for the expression of antihypertensive drug target genes were identified with expression quantitative trait loci (eQTL) in blood, which should be associated with systolic blood pressure (SBP).
View Article and Find Full Text PDFJ Mol Model
January 2025
State Key Laboratory of Polyolefins and Catalysis, Shanghai, 200062, People's Republic of China.
Context: This study aims to reveal the reaction mechanisms of H and O on the NiO(100) and Ce-doped NiO(100) surfaces using the density functional theory (DFT) combined with the on-site Coulomb correction (DFT + U) method. It was found that H and O react favorably on the reduced surfaces of both materials. However, after the oxygen vacancy is filled, the activation energy for the reaction between H₂ and lattice oxygen increases.
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