Plasma renin activity and aldosterone levels were measured radioimmunologically in 30 normal individuals subjected to antiorthostatic hypokinesia (at a - 15 degrees angle). Hormonal effects of some drugs (beta-blockers, trental, venotonics) were examined. The short-term antiorthostatic position was associated with a disordered hormonal control, reduced plasma aldosterone and enhanced plasma renin activity, as compared to the respective parameters of the reclining position. The use of beta-adreno-blockers alone or in combinations with other drugs decreases plasma renin activity in conditions of antiorthostatic hypokinesia which can be related to the inhibition of beta-adrenergic activity.
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