Drug delivery through the blood-brain barrier (BBB) is one of the key challenges in the modern era of medicine due to the highly semipermeable characteristics of BBB that restrict the entry of various drugs into the central nervous system (CNS) for the management of brain disorders. Drugs can be easily incorporated into carbon nanocarriers that can cross the bloodbrain barrier. Numerous nanocarriers have been developed, including polymeric nanoparticles, carbon nanoparticles, lipid-based nanoparticles, etc. Among these, carbon nanostructures could be superior due to their easier BBB penetration and strong biocompatibility. Several CDs (Carbon dots) and CD-ligand conjugates have explored effectively penetrating the BBB, which enables significant progress in using CD-based drug delivery systems (DDS) to manage CNS diseases. Despite the drug delivery applications, they might also be used as a central nervous system (CNS) drug; few of the carbon nanostructures show profound neurodegenerative activity. Further, their impact on neuronal growth and anti- amyloid action is quite interesting. The present study covers diverse carbon nanostructures for brain-targeted drug delivery, exploring a variety of CNS activities. Moreover, it emphasizes recent patents on carbon nanostructures for CNS disorders.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2174/0118715249305383240705045921 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Rational design of redox active metal organic frameworks for mediated electron transfer of enzymes.
Mater Horiz
January 2025
Department of Material Sciences, Institute of Pure and Applied Sciences, University of Tsukuba, 1-1-1, Tennodai, Ibaraki 305-5358, Japan.
The efficient immobilization of redox mediators remains a major challenge in the design of mediated enzyme electrode platforms. In addition to stability, the ability of the redox-active material to mediate electron transfer from the active-site buried enzymes, such as flavin adenine dinucleotide-dependent glucose dehydrogenase (FADGDH) and lactate oxidase (LOx), is also crucial. Conventional immobilization techniques can be synthetically challenging, and immobilized mediators often exhibit limited durability, particularly in continuous operation.
View Article and Find Full Text PDFSmartphone-assisted hydrogel sensing platform based on double emission carbon dots for portable on-site tetracycline detection.
Mikrochim Acta
January 2025
Department of Chemistry and Material Engineering, Lyuliang University, Lyuliang, 033000, P. R. China.
Innovative double-emission carbon dots (DE-CDs) were synthesized via a one-step hydrothermal method using fennel and m-phenylenediamine (m-PD) as precursors. These DE-CDs exhibited dual emission wavelengths at 432 and 515 nm under different excitations, making them highly versatile for fluorescence-based applications. The fluorescence of the DE-CDs was efficiently quenched by tetracycline (TC) through the inner filter effect (IFE), allowing for the construction of a sensitive dual-response fluorescent sensor.
View Article and Find Full Text PDFSimulation of Arc Discharge in an Argon/Methane Mixture, Taking into Account the Evaporation of Anode Material in Problems Related to the Synthesis of Functional Nanostructures.
Nanomaterials (Basel)
December 2024
Department of General Physics, Kazan National Research Technical University Named After A.N. Tupolev-KAI, Kazan 420111, Russia.
In this work, within the framework of a self-consistent model of arc discharge, a simulation of plasma parameters in a mixture of argon and methane was carried out, taking into account the evaporation of the electrode material in the case of a refractory and non-refractory cathode. It is shown that in the case of a refractory tungsten cathode, almost the same methane conversion rate is observed, leading to similar values in the density of the main methane conversion products (C, C, H) at different values of the discharge current density. However, with an increase in the current density, the evaporation rate of copper atoms from the anode increases, and a jump in the - characteristic is observed, caused by a change in the plasma-forming ion.
View Article and Find Full Text PDFFacile Synthesis of Mesoporous NiCoO Nanosheets on Carbon Fibers Cloth as Advanced Electrodes for Asymmetric Supercapacitors.
Nanomaterials (Basel)
December 2024
Department of Energy and Power Engineering, North University of China, Taiyuan 038507, China.
The NiCoO Nanosheets@Carbon fibers composites have been successfully synthesized by a facile co-electrodeposition process. The mesoporous NiCoO nanosheets aligned vertically on the surface of carbon fibers and crosslinked with each other, producing loosely porous nanostructures. These hybrid composite electrodes exhibit high specific capacitance in a three-electrode cell.
View Article and Find Full Text PDFTuning of Water Vapor Permeability in 2D Nanocarbon-Based Polypropylene Composite Membranes.
Nanomaterials (Basel)
December 2024
Foundation for Research and Technology-Hellas (FORTH), Institute of Chemical Engineering Sciences (ICE-HT), Stadiou Str., GR-265 04 Rio-Patras, Greece.
This work focuses on the incorporation of 2D carbon nanomaterials, such as graphene oxide (GO), reduced graphene oxide (rGO) and graphene nanoplatelets (GNPs), into polypropylene (PP) via melt mixing. The addition of these 2D carbon nanostructured networks offers a novel approach to enhancing/controlling the water vapor permeable capabilities of PP composite membranes, widely used in industrial applications, such as technical (building roof membranes) or medical (surgical gowns) textiles. The study investigates how the dispersion and concentration of these graphene nanomaterials within the PP matrix influence the microstructure and water vapor permeability (WVP) performance.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!