AI Article Synopsis
- - Autoimmune diseases are the third most common disease category worldwide, following cancer and heart disease, with long non-coding RNA (lncRNA) playing a crucial role in their regulation and pathogenesis.
- - LncRNA, which is over 200 nucleotides long, is involved in gene expression and is important for the development and activation of immune cells, linking it to autoimmune disorders.
- - The study focuses on lncRNA Ifng antisense RNA 1 (IFNG-AS1), which regulates the immune response and may be a potential therapeutic target due to its involvement in several autoimmune diseases.
Article Abstract
The prevalence of autoimmune diseases ranks as the third most common disease category globally, following cancer and heart disease. Numerous studies indicate that long non-coding RNA (lncRNA) plays a pivotal role in regulating human growth, development, and the pathogenesis of various diseases. It is more than 200 nucleotides in length and is mostly involve in the regulation of gene expression. Furthermore, lncRNAs are crucial in the development and activation of immune cells, with an expanding body of research exploring their association with autoimmune disorders in humans. LncRNA Ifng antisense RNA 1 (IFNG-AS1), a key regulatory factor in the immune system, also named NeST or TMEVPG1, is proximally located to IFNG and participates in the regulation of it. The dysregulation of IFNG-AS1 is implicated in the pathogenesis of several autoimmune diseases. This study examines the role and mechanism of IFNG-AS1 in various autoimmune diseases and considers its potential as a therapeutic target.
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| http://dx.doi.org/10.1007/s13577-024-01103-9 | DOI Listing |
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