AI Article Synopsis

  • Neonatal PICC-related thrombosis is a significant complication in infants that affects their health and safety, leading to unintended removal of catheters.
  • This study conducts a systematic review and meta-analysis to evaluate the incidence (pooled incidence of 2%) and risk factors associated with thrombosis in neonates with PICC.
  • Identified risk factors include lower extremity insertion sites, younger gestational age, specific health conditions, and prolonged hospital stays, emphasizing the need for careful management in neonatal care.

Article Abstract

Background: Catheter-related thrombosis is a common complication of the peripherally inserted central catheter (PICC) in neonates, leading to unintended tube removal and significantly affecting neonatal health and safety. Despite widespread reporting on the estimated occurrence and factors contributing to neonatal PICC-related thrombosis, these findings have not been synthesized.

Objectives: The purpose of this study was to determine the incidence and risk factors of neonatal PICC-related thrombosis.

Design: Systematic literature review and meta-analysis.

Methods: Two independent researchers systematically explored multiple databases-such as PubMed, Medline, Embase and the Cochrane Library-from their inception until October 2023. Our study aggregates and scrutinizes studies specifically addressing the incidence and risk factors of neonatal PICC-related thrombosis. Employing the RevMan 5.3 software, a meta-analysis was executed to determine the incidence of both thrombosis and odds ratios (OR), accompanied by their respective 95% confidence intervals (CI) for the risk factors.

Results: A total of 327 articles were screened, and data from 24 studies were used in synthesis. Neonatal PICC-related thrombosis incidence varied from 0.23% to 17.91%. The pooled incidence was 2% (95% CI: 1%-2%; I = 94%; p < .0001). The study identified 12 risk factors, including insertion sites in the lower extremities (OR = 0.22; 95% CI: 0.09-0.56; p = .001), gestational age <28 weeks, abdominal pathology, fresh frozen plasma by day 5 > 50 mL/kg, PICC tip location (proximal placement), two lumens, three lumens, prolonged hospital stay, infection, mothers' use of anticoagulants, patients with cardiac insufficiency and being twin-to-twin transfusion syndrome donor.

Conclusions: The analysis indicates an overall pooled incidence of neonatal PICC-related thrombosis of 2%. Twelve factors were identified as risks associated with neonatal PICC-related thrombosis. Understanding the risk factors can provide evidence-based recommendations for improving awareness, control and treatment and better nursing management.

Relevance To Clinical Practice: This systematic review and meta-analysis illuminates the incidence and risk factors linked to neonatal PICC-related thrombosis, delivering essential insights pivotal for clinical decision-making and enhancing patient care within neonatal health care settings.

Download full-text PDF

Source
http://dx.doi.org/10.1111/nicc.13121DOI Listing

Publication Analysis

Top Keywords

neonatal picc-related
16
incidence risk
12
risk factors
12
factors neonatal
12
picc-related thrombosis
12
peripherally inserted
8
inserted central
8
catheter-related thrombosis
8
determine incidence
8
incidence
6

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!