AI Article Synopsis
- Senescence leads to various health issues, making it important to find ways to target senescent cells for therapy.
- A study by Katsuumi et al. discovered that inhibiting sodium-glucose co-transporter 2 (SGLT2) enhances the immune system's ability to eliminate senescent cells through the suppression of PD-L1.
- This research could significantly impact treatments for age-related diseases like cancer and frailty.
Article Abstract
Senescence is associated with multiple morbidities and therapeutic targeting of these cells is a key aim. In a recent study, Katsuumi et al. found that targeting sodium-glucose co-transporter 2 (SGLT2) promoted immune clearance of senescent cells via programmed cell death-1 ligand (PD-L1) suppression, thus promoting immunosurveillance. This could have profound implications for many age-related diseases, including cancer and frailty.
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| http://dx.doi.org/10.1016/j.molmed.2024.07.002 | DOI Listing |
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