Background: How the joints exactly move and interact and how this reflects PD-related gait abnormalities and the response to dopaminergic treatment is poorly understood. A detailed understanding of these kinematics can inform clinical management and treatment decisions. The aim of the study was to investigate the influence of different gait speeds and medication on/off conditions on inter-joint coordination, as well as kinematic differences throughout the whole gait cycle in well characterized pwPD.
Methods: 29 controls and 29 PD patients during medication on, 8 of them also during medication off walked a straight walking path in slow, preferred and fast walking speeds. Gait data was collected using optical motion capture system. Kinematics of the hip and knee and coordinated hip-knee kinematics were evaluated using Statistical Parametric Mapping (SPM) and cyclograms (angle-angle plots). Values derived from cyclograms were compared using repeated-measures ANOVA for within group, and ttest for between group comparisons.
Results: PD gait differed from controls mainly by lower knee range of motion (ROM). Adaptation to gait speed in PD was mainly achieved by increasing hip ROM. Regularity of gait was worse in PD but only during preferred speed. The ratios of different speed cyclograms were smaller in the PD groups. SPM analyses revealed that PD participants had smaller hip and knee angles during the swing phase, and PD participants reached peak hip flexion later than controls. Withdrawal of medication showed an exacerbation of only a few parameters.
Conclusions: Our findings demonstrate the potential of granular kinematic analyses, including > 1 joint, for disease and treatment monitoring in PD. Our approach can be extended to further mobility-limiting conditions and other joint combinations.
Trial Registration: The study is registered in the German Clinical Trials Register (DRKS00022998, registered on 04 Sep 2020).
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11245779 | PMC |
| http://dx.doi.org/10.1186/s12984-024-01416-8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Determining the optimum number of cycles for calculating joint coordination and its variability during running at different speeds: A timeseries analysis.
J Biomech
November 2024
Human Motion Diagnostic Centre, University of Ostrava, Ostrava, Czech Republic; Biomechanics Laboratory, University of Massachusetts, Amherst, MA, USA. Electronic address:
Understanding the intricacies of human movement coordination and variability during running is crucial to unraveling the dynamics of locomotion, identifying potential injury mechanisms and understanding skill development. Identification of minimum number of cycles for calculation of reliable coordination and its variability could help with better test organization and efficient assessment time. By adopting a cross-sectional study design, this study investigated the minimum required cycles for calculating hip-knee, hip-ankle and knee-ankle coordination and their variability using a continuous relative phase (CRP) method.
View Article and Find Full Text PDFInfluence of medial longitudinal arch flexibility on lower limb joint coupling coordination and gait impulse.
Gait Posture
October 2024
Faculty of Sports Science, Ningbo University, Ningbo, China; Auckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand; Research Academy of Medicine Combining Sports, Ningbo NO.2 Hospital, Ningbo, China. Electronic address:
Article Synopsis
- A causal relationship exists between foot structure differences and lower limb biomechanics, contributing to musculoskeletal disorders.
- The study investigated how medial longitudinal arch flexibility influences joint coordination and ground reaction forces during walking and running in physically active males.
- Results showed that varying arch flexibility affects joint coordination and ground reaction forces, with stiffer arches leading to greater variability in certain phases of walking, and flexible arches producing more forward and backward ground reaction forces.
Lower-limb inter-joint coordination during balance recovery after trips.
Gait Posture
October 2024
Institute of Human Factors and Ergonomics, Shenzhen University, China. Electronic address:
Background: Trips are one of the most common external perturbations that can lead to accidental falls. Knowledge about postural control attributes of balance recovery after trips could help reveal the biomechanical causes for trip-induced falls and provide implications for fall prevention interventions.
Research Question: The objective of the present study was to examine coordinated lower-limb movements during balance recovery after trips.
The Kinematics of 3D Arm Movements in Sub-Acute Stroke: Impaired Inter-Joint Coordination is Attributable to Both Weakness and Flexor Synergy Intrusion.
Neurorehabil Neural Repair
September 2024
Department of Cognitive and Brain Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel.
Background: It has long been of interest to characterize the components of the motor abnormality in the arm after stroke. One approach has been to decompose the hemiparesis phenotype into negative signs, such as weakness, and positive signs, such as intrusion of synergies. We sought to identify the contributions of weakness and flexor synergy to motor deficits in sub-acute stroke.
View Article and Find Full Text PDFCorticospinal premotor fibers facilitate complex motor control after stroke.
Ann Clin Transl Neurol
September 2024
Medical Faculty, University of Cologne, and Department of Neurology, University Hospital Cologne, Cologne, Germany.
Objective: The corticospinal tract (CST) is considered the most important motor output pathway comprising fibers from the primary motor cortex (M1) and various premotor areas. Damage to its descending fibers after stroke commonly leads to motor impairment. While premotor areas are thought to critically support motor recovery after stroke, the functional role of their corticospinal output for different aspects of post-stroke motor control remains poorly understood.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!