Translation inhibition can activate two cell death pathways. The first pathway is activated by translational aberrations, the second by endoplasmic reticulum (ER) stress. In this work, the effect of ribosome-inactivating protein type II (RIP-II) viscumin on M1 macrophages derived from the THP-1 cell line was investigated. The number of modified ribosomes was evaluated by real-time PCR. Transcriptome analysis revealed that viscumin induces the ER stress activated by the PERK sensor.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11263228 | PMC |
| http://dx.doi.org/10.1134/S1607672924600301 | DOI Listing |
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