Real-world rotordynamic systems exhibit inherent uncertainties in manufacturing tolerances, material properties, and operating conditions. This study presents a Monte Carlo simulation approach using MSC Adams View and Adams Insight to investigate the impact of these uncertainties on the performance of a Laval/Jeffcott rotor model. Key uncertainties in bearing damping, bearing clearance, and mass imbalance were modeled with probabilistic distributions. The Monte Carlo analysis revealed the probabilistic nature of critical speeds, vibration amplitudes, and overall system stability. The findings highlight the importance of probabilistic methods in robust rotordynamic design and provide insights for establishing manufacturing tolerances and operational limits.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11244054 | PMC |
http://dx.doi.org/10.3390/s24134349 | DOI Listing |
Pharmaceutics
November 2024
Departamento de Ingeniería Química y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de La Laguna, Avda. Fco. Sánchez, s/n, 38200 Santa Cruz de Tenerife, Spain.
Background: The manufacture of biologics is a complex, controlled, and reproducible process that results in a product that meets specifications. This should be based on data from batches used to demonstrate manufacturing consistency. Ten batches of originator product (Avastin) were analyzed over a 10-year period.
View Article and Find Full Text PDFBiology (Basel)
December 2024
School of Intelligent Manufacturing and Equipment, Shenzhen Institute of Information Technology, Shenzhen 518172, China.
In an environmentally controlled plant factory with LED red-blue light, the effects of conventional light (4R:1B, 200 μmol·m·s, 18/6 h) and continuous light (CL, 24/0 h) with three light intensities (4R:1B, 200, 300 and 400 μmol·m·s, 24/0 h) on yield, nutritional quality, reactive oxygen species (ROS) content and 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity (DPPH) in green-leaf Yidali and purple-leaf Zishan lettuces were investigated. The results showed that the dry and fresh shoot weight of two lettuces exposed to CL tended to increase with light intensity-from 200 to 400 μmol·m·s-compared to conventional light, while the leaf area tended to decrease or remained unchanged. High-intensity CL could significantly increase soluble sugar and reduce the nitrate contents of the two lettuces.
View Article and Find Full Text PDFAcc Chem Res
January 2025
Department of Chemistry, The University of Texas at Austin, 105 East 24th Street, Austin, Texas 78712, United States.
ConspectusLight-driven polymerizations and their application in 3D printing have revolutionized manufacturing across diverse sectors, from healthcare to fine arts. Despite the popularized notion that with 3D printing "imagination is the only limit", we and others in the scientific community have identified fundamental hurdles that restrict our capabilities in this space. Herein, we describe the group's efforts in developing photochemical systems that respond to nontraditional colors of light to elicit the rapid, spatiotemporally controlled formation of plastics.
View Article and Find Full Text PDFLancet Respir Med
December 2024
Population Policy and Practice Department, UCL Great Ormond Street Institute of Child Health, University College London, London, UK; Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK. Electronic address:
Nat Med
January 2025
BioNTech US, Cambridge, MA, USA.
New treatment approaches are warranted for patients with advanced melanoma refractory to immune checkpoint blockade (ICB) or BRAF-targeted therapy. We designed BNT221, a personalized, neoantigen-specific autologous T cell product derived from peripheral blood, and tested this in a 3 + 3 dose-finding study with two dose levels (DLs) in patients with locally advanced or metastatic melanoma, disease progression after ICB, measurable disease (Response Evaluation Criteria in Solid Tumors version 1.1) and, where appropriate, BRAF-targeted therapy.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!