Human Acellular Collagen Matrices-Clinical Opportunities in Tissue Replacement.

Int J Mol Sci

Department of Trauma Surgery and Orthopaedics, University Hospital, Goethe University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.

Published: June 2024

AI Article Synopsis

  • Regenerative medicine is in need of effective materials for tissue engineering, with human acellular dermal matrix (hADM)-derived collagen matrices emerging as a promising option due to their structural integrity and biocompatibility.
  • The study explores expanded clinical uses for collagen sheets beyond their traditional applications, evaluating the potential of Epiflex, an allogeneic membrane, and highlighting its effectiveness in bone reconstruction and other orthopedic procedures.
  • The findings suggest that collagen sheets can effectively manage a variety of tissue defects, enhance patient outcomes, and reduce the need for additional surgeries, thus indicating a broader application for hADM in clinical settings.

Article Abstract

The field of regenerative medicine is increasingly in need of effective and biocompatible materials for tissue engineering. Human acellular dermal matrix (hADM)-derived collagen matrices stand out as a particularly promising candidate. Their ability to preserve structural integrity, coupled with exceptional biocompatibility, positions them as a viable choice for tissue replacement. However, their clinical application has been largely confined to serving as scaffolds. This study aims to expand the horizon of clinical uses for collagen sheets by exploring the diverse cutting-edge clinical demands. This review illustrates the clinical utilizations of collagen sheets beyond traditional roles, such as covering skin defects or acting solely as scaffolds. In particular, the potential of Epiflex, a commercially available and immediately clinically usable allogeneic membrane, will be evaluated. Collagen sheets have demonstrated efficacy in bone reconstruction, where they can substitute the induced Masquelet membrane in a single-stage procedure, proving to be clinically effective and safe. The application of these membranes allow the reconstruction of substantial tissue defects, without requiring extensive plastic reconstructive surgery. Additionally, they are found to be apt for addressing osteochondritis dissecans lesions and for ligament reconstruction in the carpus. The compelling clinical examples showcased in this study affirm that the applications of human ADM extend significantly beyond its initial use for skin defect treatments. hADM has proven to be highly successful and well-tolerated in managing various etiologies of bone and soft tissue defects, enhancing patient care outcomes. In particular, the application from the shelf reduces the need for additional surgery or donor site defects.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11241445PMC
http://dx.doi.org/10.3390/ijms25137088DOI Listing

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