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- The Editorial Office received notice about an issue concerning the original publication.
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The Editorial Office was made aware that the original publication [...].
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11243311 | PMC |
| http://dx.doi.org/10.3390/nu16131983 | DOI Listing |
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A primary function of intercalated cells in the distal tubule of the kidney is to maintain pH homeostasis. For example, type B intercalated cells secrete bicarbonate largely through the action of the apical Cl/HCO exchanger, pendrin, which helps correct metabolic alkalosis. Since both the K-Cl cotransporter, KCC3a and pendrin colocalize to the apical region of type B and non-A, non-B intercalated cells and since both are upregulated in models of metabolic alkalosis, such as with dietary NaHCO loading, we raised the possibility that apical KCC3a facilitates pendrin-mediated bicarbonate secretion, such as through apical Cl recycling.
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