AI Article Synopsis
- Migrasomes are specialized organelles formed by migrating neutrophils and play a crucial role in blood clotting (haemostasis).
- They are abundant in both mouse and human blood and enhance coagulation by binding coagulation factors and adhesion molecules, especially at injury sites.
- Reducing neutrophils or migrasomes impairs blood clot formation, but injecting purified migrasomes can restore it, suggesting their importance in coagulation disorders and potential for new treatments.
Article Abstract
Migrasomes are organelles that are generated by migrating cells. Here we report the key role of neutrophil-derived migrasomes in haemostasis. We found that a large number of neutrophil-derived migrasomes exist in the blood of mice and humans. Compared with neutrophil cell bodies and platelets, these migrasomes adsorb and enrich coagulation factors on the surface. Moreover, they are highly enriched with adhesion molecules, which enable them to preferentially accumulate at sites of injury, where they trigger platelet activation and clot formation. Depletion of neutrophils, or genetic reduction of the number of these migrasomes, significantly decreases platelet plug formation and impairs coagulation. These defects can be rescued by intravenous injection of purified neutrophil-derived migrasomes. Our study reveals neutrophil-derived migrasomes as a previously unrecognized essential component of the haemostasis system, which may shed light on the cause of various coagulation disorders and open therapeutic possibilities.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11251984 | PMC |
| http://dx.doi.org/10.1038/s41556-024-01440-9 | DOI Listing |
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