AI Article Synopsis
- The study investigates the effectiveness and safety of aspirin versus various anticoagulants in preventing venous thromboembolism (VTE) after revision total joint arthroplasty (TJA).
- A retrospective analysis of 4,575 patients revealed that those taking aspirin had a significantly lower incidence of symptomatic VTE (0.53%) compared to those on other anticoagulants (2.54%).
- The findings suggest that aspirin may be a safer and equally effective option for VTE prophylaxis in revision TJA, emphasizing the importance of considering individual patient risks when choosing a prophylactic agent.
Article Abstract
Background: Venous thromboembolism (VTE) following revision total joint arthroplasty (TJA) poses significant risks despite prophylactic measures. The optimal VTE prophylaxis agent for revision TJA remains unclear. This study aimed to compare aspirin against various anticoagulant agents regarding efficacy and safety in preventing symptomatic VTE events after revision TJA.
Methods: A retrospective analysis included 4,575 patients undergoing revision TJA between 2008 and 2020. Of these, 2,091 received aspirin, while 2,484 received other anticoagulants. Demographic, procedural, and outcome data were collected. Logistic regression models were used to identify predictors of symptomatic VTE.
Results: The aspirin group showed a significantly lower incidence of symptomatic VTE compared to the other anticoagulant group (0.53 versus 2.54%, P < .001). Logistic regression confirmed a higher risk of VTE with other anticoagulants (odds ratio: 0.2 to 0.26, P < .001), while blood transfusion (odds ratio: 2.72, P = .001) were identified as risk factors.
Conclusions: This study demonstrated that aspirin is a viable and potentially safer option than other anticoagulants, exhibiting comparable efficacy in preventing VTE events in revision TJA. Balancing effectiveness and safety is crucial, considering patient-specific risk factors and bleeding tendencies. This large cohort study demonstrated that aspirin was associated with a more effective and safer VTE prophylaxis agent, compared to other anticoagulants, in patients undergoing revision TJA.
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| http://dx.doi.org/10.1016/j.arth.2024.06.061 | DOI Listing |
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