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Hepatoprotective effects of resveratrol on α-amanitin-induced liver toxicity in rats. | LitMetric

AI Article Synopsis

  • This study examined how resveratrol can protect the liver from damage caused by α-Amanitin (α-AMA) in rats, focusing on factors like oxidative stress and inflammation.
  • Rats were divided into four groups for the experiment: a control group, a resveratrol-only group, an α-AMA-only group, and a group receiving both resveratrol and α-AMA, with various treatments administered over eight days.
  • Results showed that while α-AMA caused significant liver damage and increased oxidative stress, resveratrol treatment helped reduce liver enzyme levels, oxidative stress markers, and inflammation, and improved overall liver function.

Article Abstract

Objective: The hepatoprotective effects of resveratrol against α-Amanitin (α-AMA)-induced liver toxicity were investigated in an experimental rat model, focusing on oxidative stress, inflammation, apoptosis, and liver function.

Methods: Thirty-two male Sprague-Dawley rats were divided into four groups (n = 8 per group): Control, resveratrol, α-AMA, and resveratrol+α-AMA. The resveratrol group received 20 mg/kg resveratrol orally for 7 days. The α-AMA group received 3 mg/kg α-AMA intraperitoneally on the 8th day. The resveratrol+α-AMA group received 20 mg/kg resveratrol orally (7 days) followed by 3 mg/kg α-AMA intraperitoneally on the 8th day. Liver tissues and blood samples were collected 48 h after α-amanitin administration for histopathological, immunohistochemical (NFkB, LC3B), and biochemical analyses (GSH, MDA, CAT, GPx, MPO, NOS, AST, ALT).

Results: α-AMA significantly increased AST and ALT levels, oxidative stress marker (MDA), and inflammatory marker (MPO), while reducing antioxidant levels (GSH, CAT, GPx) and NOS concentration (P < 0.001 for all parameters). Histopathological analysis showed severe liver damage with increased NFkB and LC3B expression. resveratrol treatment significantly reduced AST and ALT levels (P < 0.01 for both parameters), decreased MDA and MPO levels, and increased NOS concentration, GSH, CAT, and GPx levels (P < 0.05 for all parameters). Reduced NFkB and LC3B expression in the resveratrol+α-AMA group and showed histopathological improvements.

Conclusion: Resveratrol demonstrated substantial hepatoprotective effects against α-AMA induced liver toxicity by reducing oxidative stress, inflammation, and apoptosis, and improving liver function. These findings suggest that resveratrol could be a potential therapeutic agent for treating liver damage caused by potent hepatotoxins like α-AMA.

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Source
http://dx.doi.org/10.1016/j.toxicon.2024.107855DOI Listing

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