Squishy to crusty: Biophysics reveal the molecular details of FUS droplet maturation.

Structure

Greehey Children's Cancer Research Institute and Department of Biochemistry and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA. Electronic address:

Published: July 2024

In a recent issue of Nature Chemical Biology, Emmanouilidis et al. (2024) investigate the maturation of biomolecular condensates of FUS and probe the molecular details of droplet aging. They observe that the liquid-to-solid transition of the droplet is mediated at the surface by FUS molecules that have adopted β-strand conformations.

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http://dx.doi.org/10.1016/j.str.2024.06.007DOI Listing

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