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Biomimetic Mineralized Hydroxyapatite-Fish-Scale Collagen/Chitosan Nanofibrous Membranes Promote Osteogenesis for Periodontal Tissue Regeneration. | LitMetric

AI Article Synopsis

  • Commercial collagen-based membranes for guided tissue regeneration (GTR) in periodontal repair face issues like ethical concerns and limited bone regeneration efficiency.
  • A new enhanced biomimetic membrane combining mineralized hydroxyapatite with grass carp fish scale collagen and chitosan was developed to improve tissue regeneration.
  • In lab and rat studies, the new HAp-FCOL/CS membranes showed no cytotoxicity, supported cell growth, and significantly improved bone regeneration, making them a promising and eco-friendly alternative for periodontal treatments.

Article Abstract

Commercial mammalian collagen-based membranes used for guided tissue regeneration (GTR) in periodontal defect repair still face significant challenges, including ethical concerns, cost-effectiveness, and limited capacity for periodontal bone regeneration. Herein, an enhanced biomimetic mineralized hydroxyapatite (HAp)-fish-scale collagen (FCOL)/chitosan (CS) nanofibrous membrane was developed. Specifically, eco-friendly and biocompatible collagen extracted from grass carp fish scales was co-electrospun with CS to produce a biomimetic extracellular matrix membrane. An enhanced biomimetic mineralized HAp coating provided abundant active calcium and phosphate sites, which promoted cell osteogenic differentiation, and showed greater in vivo absorption. In vitro experiments demonstrated that the HAp-FCOL/CS membranes exhibited desirable properties with no cytotoxicity, provided a mimetic microenvironment for stem cell recruitment, and induced periodontal ligament cell osteogenic differentiation. In rat periodontal defects, HAp-FCOL/CS membranes significantly promoted new periodontal bone formation and regeneration. The results of this study indicate that low-cost, eco-friendly, and biomimetic HAp-FCOL/CS membranes could be promising alternatives to GTR membranes for periodontal regeneration in the clinic.

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Source
http://dx.doi.org/10.1021/acsbiomaterials.4c00569DOI Listing

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