AI Article Synopsis
- - A Ukrainian patient was found to have an extensively drug-resistant (XDR) strain of tuberculosis with a specific rifampicin resistance mutation (RpoB I491F), which is not identified by standard testing methods.
- - This situation highlights the difficulties in detecting and treating XDR-tuberculosis due to limitations in current rapid diagnostics recommended by the WHO.
- - There is a pressing need for improved diagnostic tools and customized treatment plans, particularly in eastern Europe where these challenging strains are more common.
Article Abstract
This report documents the case of a Ukrainian patient infected with an extensively drug-resistant (XDR) lineage 2 strain harbouring the rifampicin resistance mutation RpoB I491F. This mutation is not detected by routine molecular WHO-recommended rapid diagnostics, complicating the detection and treatment of these strains. The occurrence of such mutations underscores the need for enhanced diagnostic techniques and tailored treatment regimens, especially in eastern Europe where lineage 2 strains and XDR-tuberculosis are prevalent.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11241856 | PMC |
| http://dx.doi.org/10.2807/1560-7917.ES.2024.29.28.2400420 | DOI Listing |
Publication Analysis
Top Keywords
rpob i491f
8
i491f mutation
8
ukrainian patient
8
detection xdr
4
xdr clinical
4
clinical isolate
4
isolate harbouring
4
harbouring rpob
4
mutation ukrainian
4
patient treated
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!