The characterization of neural signatures within the somatosensory pathway is essential for elucidating the pathogenic mechanisms of central post-stroke pain (CPSP) and developing more effective treatments such as deep brain stimulation (DBS). We explored the characteristics of thalamic neural oscillations in response to varying pain levels under multi-day local field potential (LFP) recordings and examined the influences of continuous DBS on these thalamic activities. We recorded LFPs from the left ventral posterolateral thalamus (VPL) of a patient with CPSP in the resting state under both off- and on-stimulation conditions. We observed significant differences in the power spectral density (PSD) of different pain levels in the delta, theta and gamma frequency bands of the left VPL; 75Hz DBS significantly increased the PSD of delta and decreased the PSD of low-beta, while 130Hz DBS significantly reduced the PSD of theta and low-beta. Thalamic stimulation modulated the neural oscillations related to pain, and the changes in neural activities in response to stimulation could serve as quantitative indicators for pain relief.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11237941 | PMC |
| http://dx.doi.org/10.1016/j.heliyon.2024.e32535 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Processes and measurements: a framework for understanding neural oscillations in field potentials.
Trends Cogn Sci
January 2025
Machine Learning in Science, Excellence Cluster Machine Learning and Tübingen AI Center, University of Tübingen, Tübingen, Germany. Electronic address:
Various neuroscientific theories maintain that brain oscillations are important for neuronal computation, but opposing views claim that these macroscale dynamics are 'exhaust fumes' of more relevant processes. Here, we approach the question of whether oscillations are functional or epiphenomenal by distinguishing between measurements and processes, and by reviewing whether causal or inferentially useful links exist between field potentials, electric fields, and neurobiological events. We introduce a vocabulary for the role of brain signals and their underlying processes, demarcating oscillations as a distinct entity where both processes and measurements can exhibit periodicity.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
Department of Bioengineering, University of California, Los Angeles, CA, USA, Los Angeles, CA, USA.
Background: Alzheimer's disease (AD) is characterized by cognitive decline and increased seizure susceptibility due to brain damage and neural disruptions. This study examines the relationship between cognitive deterioration and seizure pathology in hAPP-J20 transgenic Alzheimer's mice, a model known for amyloid plaque deposition and heightened seizure activity.
Method: We observed hAPP-J20 mice aged 8 to 28 weeks using long-term wireless telemetry to assess hippocampal local field potential, sampled at 2 kHz.
Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Background: The human brain is a complex inter-wired system that emerges spontaneous functional fluctuations. In spite of tremendous success in the experimental neuroscience field, a system-level understanding of how brain anatomy supports various neural activities remains elusive.
Method: Capitalizing on the unprecedented amount of neuroimaging data, we present a physics-informed deep model to uncover the coupling mechanism between brain structure and function through the lens of data geometry that is rooted in the widespread wiring topology of connections between distant brain regions.
Influence of early-life stress on hippocampal synaptic and network properties.
Front Neural Circuits
January 2025
Federal Center of Brain Research and Neurotechnologies, Moscow, Russia.
According to the World Health Organization, the number of people suffering from depressive disorders worldwide is approaching 350 million. The consequences of depressive disorders include considerable worsening of the quality of life, which frequently leads to social isolation. One of the key factors which may cause depression in adulthood is early life stress, in particular, insufficient maternal care during infancy.
View Article and Find Full Text PDFNeural oscillations predict flow experience.
Cogn Neurodyn
December 2025
Department of Psychological and Cognitive Sciences, Tsinghua University, Beijing, 100084 China.
Flow experience, characterized by immersion in the activity at hand, provides a motivational boost and promotes positive behaviors. However, the oscillatory representations of flow experience are still poorly understood. In this study, the difficulty of the video game was adjusted to manipulate the individual's personalized flow or non-flow state, and EEG data was recorded throughout.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!