Aim: Parental adverse childhood experiences (ACE) might affect the offspring health through intergenerational inheritance. The aim of this study was to investigate how paternal ACE associate with offspring sensitisation and allergic rhinitis (AR).
Methods: The study included 590 Finnish father-child dyads from the FinnBrain Birth Cohort Study. Outcomes were offspring sensitisation against allergens and AR at age 5.5 years. Paternal ACE up to 18 years were assessed using the Trauma and Distress Scale (TADS) with the lowest quarter as the reference group.
Results: Of the children, 317 (54%) were males. Sensitisation occurred in 162/533 (30%) and AR in 122/590 (21%). Paternal TADS (median 17 points; interquartile range 11-27) was inversely associated with the risk of sensitisation. Children whose fathers scored the highest quarter had the lowest risk of sensitisation (adjusted odds ratio 0.42; 95% confidence interval 0.24-0.75), followed by those in the second highest quarter (0.58; 0.34-0.99). The association between the highest quarter and reduced risk of AR was similar.
Conclusion: Paternal ACE were associated with a low risk of offspring sensitisation and AR, suggesting paternal childhood stress might influence immune responses in their offspring.
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http://dx.doi.org/10.1111/apa.17345 | DOI Listing |
Popul Res Policy Rev
August 2024
The RAND Corporation, Santa Monica, USA.
Adverse childhood events (ACE) may have lasting consequences throughout the life course. We focus on one particular type of ACE, parental loss in Cambodia-a country that lost nearly 25% of its population during the 1975-79 Khmer-Rouge regime-and on mental health disorders, one of the potential mechanisms through which ACE may have long-term consequences. Self-reports of symptoms that map on to the Diagnostic and Statistical Manual of Mental Health Disorders (DSM) criteria for anxiety, depression, and post-traumatic stress disorder (PTSD) were collected from 4,405 adults aged 20 and over.
View Article and Find Full Text PDFAnn Clin Epidemiol
April 2024
Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo.
Acta Paediatr
November 2024
FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, Faculty of Medicine, University of Turku, Turku, Finland.
Aim: Parental adverse childhood experiences (ACE) might affect the offspring health through intergenerational inheritance. The aim of this study was to investigate how paternal ACE associate with offspring sensitisation and allergic rhinitis (AR).
Methods: The study included 590 Finnish father-child dyads from the FinnBrain Birth Cohort Study.
Front Public Health
December 2023
School of Nursing, Shanghai Jiao Tong University, Shanghai, China.
Background: Adverse childhood experiences (ACEs) have been associated with addictions such as substance use disorders. Few have examined ACEs on internet gaming disorder (IGD) as a newly established behavioral addiction, and the potential mediating role of insomnia remains unclear. We examined the associations between ACE number and types, IGD, and insomnia.
View Article and Find Full Text PDFJ Physiol Anthropol
December 2023
Institute of Human Biology and Evolution, Faculty of Biology, Adam Mickiewicz University, 61-614, Poznan, Poland.
Background: Overweight and obesity among children have become significant global health concerns. Previous studies have highlighted the potential role of genetic factors, particularly polymorphisms in the FTO and MC4R genes, as well as environmental factors in the development of childhood obesity. This study aimed to investigate the relationships between genetic, socioeconomic and perinatal factors, adverse childhood events (ACEs), and lifestyle, and their impact on overweight, obesity and body composition parameters in children.
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