Background: This historical narrative examines the early life of Dr. James Franklin Osman Adewale Ishola Mustaffah and his pivotal role in laying the foundations and advancing the field of neurosurgery in Ghana.
Methods: The creation of this project was driven by the exploration of original scientific and bibliographical works concerning Dr. Mustaffah. It details his initial endeavors to shape the landscape of neurosurgery in Ghana and Africa.
Results: This historical account follows the remarkable journey of Dr. Mustaffah, spanning from his early education in Ghana, through his college years and medical training in London, to his distinguished career in neurosurgery. It explores his groundbreaking position as the first Ghanaian neurosurgeon and his contributions to establishing neurosurgery as a recognized practice in Ghana. We commemorate the life and legacy of Dr. Mustaffah, a visionary neurosurgeon whose profound influence has motivated numerous medical professionals in Africa and beyond.
Conclusions: This article illuminates the extraordinary life and lasting legacy of Dr. Mustaffah, a pioneering neurosurgeon whose contributions have significantly shaped the trajectory of neurosurgical practice in Ghana and throughout Africa.
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http://dx.doi.org/10.1016/j.wneu.2024.07.038 | DOI Listing |
Br J Radiol
January 2025
Department of Radiology, University College London Hospitals, London, NW1 2BU, UK.
Objectives: Predicting longer term response to biological therapy for small bowel Crohn's disease (SBCD) is an unmet clinical need. Diffusion-weighted MR imaging (DWI) may indicate disease activity, but its predictive ability, if any, is unknown. We investigated the prognostic value of DWI for one year response or remission (RoR) in SBCD patients commencing biologic therapy, including incremental value over C-reactive protein (CRP) and faecal calprotectin (FC).
View Article and Find Full Text PDFJAMA Netw Open
December 2024
Renal and Metabolic Division, The George Institute for Global Health, University of New South Wales, Sydney, Australia.
Importance: Chronic kidney disease (CKD) is a global health priority affecting almost 1 billion people. New therapeutic options and clinical trial innovations such as adaptive platform trials provide an opportunity to efficiently test combination therapies.
Objective: To describe the design and baseline results of the Global Kidney Patient Trials Network (GKPTN) and the design and structure of the global adaptive platform clinical trial Chronic Kidney Disease Adaptive Platform Trial Investigating Various Agents for Therapeutic Effect (CAPTIVATE) to find new therapeutic options and treatments for people with kidney disease.
Cureus
February 2024
Family Medicine, Carilion Clinic, Roanoke, USA.
Trials
February 2024
Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford, OX3 7DQ, UK.
Mol Cell Neurosci
December 2023
Department of Pharmaceutical and Biomedical Sciences, The University of Georgia College of Pharmacy, 357 Wilson Pharmacy, Athens, GA 30602, USA. Electronic address:
A BAX- and mitochondria-dependent production of reactive oxygen species (ROS) and reactive species (reactive nitrogen species, RNS) lying downstream of these ROS occurs in apoptotic and nonapoptotic mouse sympathetic neurons and cerebellar granule cells in cell culture. These ROS have been shown to lie downstream of caspase 3 in mouse sympathetic neurons. Here we show that BAX is necessary for similar ROS production in apoptotic and nonapoptotic mouse cortical neurons in cell culture and that it also positively regulates oxidative stress in the brains of mice of different ages.
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