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METTL4-Mediated Mitochondrial DNA N6-Methyldeoxyadenosine Promoting Macrophage Inflammation and Atherosclerosis.
Circulation
December 2024
Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Nanjing Medical University, China. (L.Z., X.C., X.H., Y.T., J.M., Xinyu Li, H.W., M.C., Y.Z., M.D., Q.Y., D.H., H.J., Xuesong Li, H.C.).
Background: Mitochondrial dysfunction is a key factor in the development of atherogenesis. METTL4 (methyltransferase-like protein 4) mediates N6- methyldeoxyadenosine (6mA) of mammalian mitochondrial DNA (mtDNA). However, the role of METTL4-mediated mitoepigenetic regulation in atherosclerosis is still unknown.
View Article and Find Full Text PDFInhibition of METTL4: Targeting a Methyltransferase that Alleviates Heart Failure by Modulating Excess N6-Methyladenine in Mitochondrial DNA.
J Cardiovasc Transl Res
October 2024
Shanghai Applied Radiation Institute, School of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, China.
METTL14-mediated N6-methyladenosine modification of Col17a1/Itgα6/Itgβ4 governs epidermal homeostasis.
J Dermatol Sci
December 2023
Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:
Background: N6-methyladenosine (mA) is the most abundant and reversible modification occurring in eukaryotic mRNAs, however, its functions in mammalian epidermal development are still not fully elucidated.
Objective: To explore the role of METTL14 (Methyltransferase like 14), one of the mA methyltransferases, in maintaining epidermal homeostasis.
Methods: We constructed mice with Mettl14-inactivation in the epidermal basal cells.
METTL3/14 and IL-17 signaling contribute to CEBPA-DT enhanced oral cancer cisplatin resistance.
Oral Dis
April 2023
Department of Central Laboratory, School and Hospital of Stomatology, Liaoning Provincial Key Laboratory of Oral Disease, China Medical University, Shenyang, China.
Objectives: Oral squamous cell carcinoma (OSCC) is the most common head and neck cancer. Chemotherapy has been recognized as an optional combination treatment, which enhance the overall survival of OSCC patients. However, the majority of patients would suffer therapeutic resistance, which led to the treatment failure and poor prognosis.
View Article and Find Full Text PDFInteraction with WTAP Promotes Assembly and Activity of the mA Methyltransferase Complex and Promotes Cisplatin Resistance in Bladder Cancer.
Cancer Res
December 2021
Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P.R. China.
Cisplatin (CDDP)-based chemotherapy is the first-line treatment for muscle-invasive and metastatic bladder cancer, yet most patients rapidly develop resistance. N6-methyladenosine (mA) methylation is a pervasive RNA modification, and its specific role and potential mechanism in the regulation of CDDP chemosensitivity in bladder cancer remain unclear. Furthermore, studies have not yet fully elucidated whether circular RNA (circRNA) can directly regulate mA modification of mRNA.
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