It has been shown in experiments on adult random-bred and BALB/c Sto mice that oral infection with human strain of E. coli N-10407 induces enterocolitis characterized by marked diarrheal syndrome but without lethal outcome. The action of the strain not colonizing the intestinal mucosa of mice may be accounted for by a weak cytopathic effect of the infecting microorganism and its toxin. The data obtained indicate that adult mice may serve as a convenient model for investigation of colibacillary diarrhea induced by enterotoxigenic strain of E. coli, BALB/c Sto mice being a more sensitive model than random-bred animals.
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