AI Article Synopsis
- * It analyzed samples from over 55,000 individuals and identified significant increases in antibody prevalence, particularly during vaccination phases, achieving over 90% seroprevalence by July 2022.
- * The findings highlight the evolving patterns of immunity in a diverse urban population, indicating how responses to the virus have shifted as the pandemic transitions towards an endemic state.
Article Abstract
Sero-monitoring provides context to the epidemiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and changes in population immunity following vaccine introduction. Here, we describe results of a cross-sectional hospital-based study of anti-spike seroprevalence in New York City (NYC) from February 2020 to July 2022, and a follow-up period from August 2023 to October 2023. Samples from 55,092 individuals, spanning five epidemiological waves were analyzed. Prevalence ratios (PR) were obtained using Poisson regression. Anti-spike antibody levels increased gradually over the first two waves, with a sharp increase during the 3rd wave coinciding with SARS-CoV-2 vaccination in NYC resulting in seroprevalence levels >90% by July 2022. Our data provide insights into the dynamic changes in immunity occurring in a large and diverse metropolitan community faced with a new viral pathogen and reflects the patterns of antibody responses as the pandemic transitions into an endemic stage.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11239669 | PMC |
| http://dx.doi.org/10.1038/s41467-024-50052-2 | DOI Listing |
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