AI Article Synopsis
- - The review examines how the antisaccadic task helps understand inhibitory processes in various basal ganglia disorders, like Parkinson's disease and Tourette syndrome, highlighting different saccadic profiles among them.
- - It focuses on two key inhibitory mechanisms: one that quickly suppresses strong responses (global, pre-emptive inhibition) and another that takes longer to inhibit specific responses (slower, selective response inhibition).
- - The antisaccadic task is useful in clinical settings for diagnosis and treatment monitoring, and future improvements should include standardizing eye-tracking methods and combining this data with other indicators of disease.
Article Abstract
This review explores the role of the antisaccadic task in understanding inhibitory mechanisms in basal ganglia disorders. It conducts a comparative analysis of saccadic profiles in conditions such as Parkinson's disease, Tourette syndrome, obsessive-compulsive disorder, Huntington's disease, and dystonia, revealing distinct patterns and proposing mechanisms for impaired performance. The primary focus is on two inhibitory mechanisms: global, pre-emptive inhibition responsible for suppressing prepotent responses, and slower, selective response inhibition. The antisaccadic task demonstrates practicality in clinical applications, aiding in differential diagnoses, treatment monitoring and reflecting gait control. To further enhance its differential diagnostic value, future directions should address issues such as the standardization of eye-tracking protocol and the integration of eye-tracking data with other disease indicators in a comprehensive dataset.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.cortex.2024.06.005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!