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Early results of an orthoplastic multidisciplinary approach to diabetic foot ulcer soft tissue reconstruction.
J Wound Care
December 2024
Department of Plastic, Reconstructive, and Aesthetic Surgery, Sengkang General Hospital, Singapore.
Objective: Diabetic foot ulcer (DFU) is a common complication in patients with diabetes. With current treatment, only two-thirds of patients heal, with a median duration of 3-6 months. Hard-to-heal DFUs are a major source of morbidity and mortality.
View Article and Find Full Text PDFA review of consent policies in Dermatological Surgery in the United Kingdom and the impact of leaner pathways and teledermatology on consent.
Clin Exp Dermatol
November 2024
Department of Dermatology, Walsall Healthcare NHS Trust, UK.
Obtaining valid consent is an ethical and legal requirement in clinical practice, ensuring patients are adequately informed about their treatments. Recent updates in consent policies, including GMC guidance, the Patterson inquiry report, and key legal rulings like Montgomery, emphasise a shift towards patient-centred care and the importance of a comprehensive patient-clinician dialogue. Budget constraints and increasing NHS demand have led to the adoption of digital solutions and streamlined pathways, such as teledermatology and direct booking to surgery, potentially compromising the consent process.
View Article and Find Full Text PDFEstablishing a national biosafety and biosecurity agency for the United States.
Front Bioeng Biotechnol
October 2024
Schar School of Policy and Government, George Mason University, Arlington, VA, United States.
The rapid advancement of biological research and biotechnology requires a novel and robust regulatory agency to ensure uniform biosafety and biosecurity governance in the United States. The current fragmented regulatory landscape needs to be refocused to address the complexities of modern biological research, including risks associated with accidental, inadvertent, and deliberate biological incidents. An independent government agency, which we call the National Biosafety and Biosecurity Agency (NBBA), that is devoted to biosafety and biosecurity could effectively address these challenges.
View Article and Find Full Text PDFCombining Ultrasonography and Endometrial Aspiration as a One-Stop Screening for Endometrial Neoplasia.
Obstet Gynecol
December 2024
Department of Obstetrics & Gynecology and Women's Health, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, the Department of Obstetrics & Gynecology and Gynecologic Oncology, LIJ Medical Center, Northwell Health, New Hyde Park, and the Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York; the Division of Gynecologic Oncology, Stanford University School of Medicine, Stanford, California; the Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland; and the Department of Obstetrics and Gynecology, University Hospital Leuven, and the Department of Development and Regeneration, KU Leuven, Leuven, Belgium.
Article Synopsis
- The study aimed to evaluate the effectiveness of combining endometrial aspiration and sonohysterography for screening endometrial cancer and hyperplasia in women over 50.
- Conducted from February 2014 to October 2020, the study involved 1,170 women, revealing significant findings: 7% were diagnosed with cancer, and 3.6% with hyperplasia, with most cancers detected within a year.
- The combined screening method showed high sensitivity (99.1%) but lower specificity (24.9%), while a sequential approach improved specificity and positive predictive value, indicating that the combined method is a promising tool for detecting endometrial issues.
Streamlining of Simple Sequence Repeat Data Mining Methodologies and Pipelines for Crop Scanning.
Plants (Basel)
September 2024
Rice Breeding Innovation Platform, International Rice Research Institute (IRRI), Los Baños 4031, Laguna, Philippines.
Genetic markers are powerful tools for understanding genetic diversity and the molecular basis of traits, ushering in a new era of molecular breeding in crops. Over the past 50 years, DNA markers have rapidly changed, moving from hybridization-based and second-generation-based to sequence-based markers. Simple sequence repeats (SSRs) are the ideal markers in plant breeding, and they have numerous desirable properties, including their repeatability, codominance, multi-allelic nature, and locus specificity.
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