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Long-term observation of the in vivo safety of a new design of phakic refractive lens.
BMC Ophthalmol
January 2025
Fudan University Eye Ear Nose and Throat Hospital, Shanghai, China.
Background: To evaluate the biosafety, reduction in anterior capsule opacification, and fluctuation in intraocular pressure (IOP) of a new phakic refractive lens (PRL) with a sinusoidal drainage groove design.
Methods: This self-controlled experiment was performed on eight eyes of four rabbits. Each rabbit was implanted with a sinusoidal PRL (PRL-S5) in the right eye and a conventional posterior chamber PRL (PC-PRL) in the left eye.
Detecting Monkeypox Virus by Immunohistochemistry.
J Cutan Pathol
December 2024
Department of Dermatology, University of Virginia, Charlottesville, Virginia, USA.
Background: Mpox (formerly known as monkeypox), a zoonotic disease caused by Monkeypox virus (MPXV), has become an international outbreak since May 2022. Mpox often presents with a mild systemic illness and a characteristic vesiculopustular skin eruption. In addition to molecular testing, histopathology of cutaneous lesions usually shows distinctive findings, such as epidermal necrosis, balloon degeneration, papillary dermal edema, and focal dermal necrosis, which have proven helpful in the diagnosis of mpox.
View Article and Find Full Text PDFAnalysis of periodontal status in Polish patients with rheumatoid arthritis treated with biological therapies.
Reumatologia
November 2024
Chair and Department of Dental Surgery, Periodontology, and Oral Mucosa Diseases, Poznan University of Medical Sciences, Poland.
Introduction: Periodontitis, characterized by inflammation affecting the tooth-supporting tissues, may increase the risk of rheumatoid arthritis (RA) or cardiovascular diseases. The aim of the study was to evaluate the periodontal status in RA patients and its impact on the inflammatory markers and red cell parameters obtained from complete blood laboratory tests to study the risk of cardiovascular disease development.
Material And Methods: The cross-sectional study included 50 patients with RA treated with biological therapies: tumor necrosis factor inhibitors, interleukin-6 blockers.
A 33-year-old female presented with coryzal symptoms, facial swelling, severe haemorrhagic stomatitis, blistering oral mucositis, conjunctival injection and a sparse targetoid rash on the back and face, requiring admission to hospital. She had received the seasonal influenza vaccination 3 days prior to feeling unwell. Differential diagnosis included erythema multiforme major (EMM) secondary to the influenza vaccine or Mycoplasma pneumoniae-induced rash and mucositis (MIRM).
View Article and Find Full Text PDFHigh Expression of Immune Checkpoint Molecules in Different Types of Thyroid Cancer.
Iran J Allergy Asthma Immunol
October 2024
Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran AND Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Article Synopsis
- * Samples from 100 patients with various types of thyroid carcinoma were analyzed, revealing high levels of PD-1 in tumor-infiltrating lymphocytes (88%) and PD-L1 in tumor cells (30%).
- * Findings showed that increased PD-1 and PD-L1 expression correlates with advanced disease stages and may indicate potential for targeted immunotherapy, particularly in anaplastic thyroid carcinoma.
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