Abnormal uterine bleeding (AUB) is an acute/chronic variation in the normal menstrual cycle that affects adolescents, women of reproductive age and perimenopausal women. AUB affects approximately 3-30% of reproductive-aged women worldwide, and reduces their quality of life and productivity whilst increasing the overall healthcare burden. Its management requires thorough medical evaluation and individualized treatment. Depending on the severity and cause of AUB, its treatment ranges from lifestyle modifications and hormonal therapies to more invasive procedures or surgery. Although hormonal therapy is the preferred first-line measure in AUB, the available pharmacological options have various adverse effects. There exists a need for safer and more efficient treatment regimens with high patient compliance to effectively treat AUB. Norethisterone, also known as norethindrone, is a widely used synthetic analogue of progestogen. Controlled release formulations of norethisterone/ norethisterone acetate help maintain constant drug levels in the blood and exert minimal side-effects; therefore, they are promising therapeutic agents for effective AUB management. The present review summarizes the epidemiology and diagnosis of AUB, with a focus on the safety, efficacy and tolerability of norethisterone/ norethisterone acetate in AUB management. We also report a case of AUB in a 40-year-old woman, who was treated with NETA tablets. The treatment resulted in favourable outcomes, and patient satisfaction.
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http://dx.doi.org/10.7573/dic.2024-4-1 | DOI Listing |
Sci Total Environ
December 2024
Ottawa Research and Development Centre, Agriculture and Agri-Food Canada, 960 Carling Avenue, Ottawa K1A 0C6, ON, Canada. Electronic address:
Water scarcity is a growing challenge in semi-arid regions. Many farmers have resorted to treated wastewater (TWW) as an available and low-cost water source. This study investigated the impact of irrigating potato (Solanum Tuberosum) and corn (Zea mays) with tertiary-treated (TW) and secondary-treated (SW) wastewater compared to freshwater, over two years.
View Article and Find Full Text PDFNutr Metab (Lond)
December 2024
Department of Gynecology, Shenzhen Second People's Hospital, The First Affiliated Hospital ofShenzhen UniversityHealth Science Center, Shenzhen, 518000, China.
Background: Abnormal uterine bleeding (AUB) is a common gynecological issue during reproductive years. Researches on how dietary diversity and patterns influence AUB in Chinese university students are limited, with some studies not clearly defining irregular menstruation. This research investigated the incidence of AUB according to the International Federation of Gynecology and Obstetrics criteria and sought to identify preventative factors via online questionnaires.
View Article and Find Full Text PDFBMC Nurs
December 2024
Ministry of Public Health, Beirut, Lebanon.
Background: Primary Health Care (PHC) is the cornerstone of any healthcare system, with nurses forming the largest workforce involved in care. This study aimed to assess the current use of core competencies among community-based nurses, identify their learning needs, and assess factors associated with training needs within PHC centers.
Methods: A quantitative cross-sectional survey design was used, targeting community health nurses working within primary healthcare centers.
J Pediatr Adolesc Gynecol
December 2024
University of Health Sciences, Department of Pediatric Hematology, Ankara Training and Research Hospital, 06230, Ankara, Turkey.
Objective: There is a relative lack of research on the association of mental health problems and menstrual-related concerns in adolescents. The objective of the current study was to compare anxiety, depression, quality of life, and perceived stress between adolescents with abnormal uterine bleeding (AUB) and control patients.
Study Design: We performed a cross-sectional study in which participants were recruited from a tertiary training and research hospital.
Immunogenetics
December 2024
Department of Anatomy, Cell Biology and Physiological Sciences, American University of Beirut, Beirut, Lebanon.
Syndecan-1 (SDC-1) is a transmembrane protein localized on the basolateral surface of epithelial cells, encompassing a core protein with heparin sulfate and chondroitin sulfate glycosaminoglycan side chains. SDC-1 is involved in a panoply of cellular mechanisms including cell-to-cell adhesion, extracellular matrix interactions, cell cycle modulation, and lipid clearance. Alterations in the expression and function of SDC-1 are implicated in numerous disease entities, making it an attractive diagnostic and therapeutic target.
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