Atypical presentation of molluscum contagiosum infection in a human immunodeficiency virus-positive patient.

Molluscum contagiosum (MC) is a skin infection caused by a virus of the poxvirus family. The infection is usually innocuous and inconsequential, occasionally resolving spontaneously. It is rarely associated with such severe physical and psychological morbidity. The clinical lesions are usually painless papules or nodules with central umbilication. Painful anogenital tumors exhibiting a cerebriform surface have rarely been reported. MC infection in human immunodeficiency virus (HIV)-infected patients may present with generalized papules and papulonodules, and sometimes, progression to tumorous lesions. Early detection and effective treatment of the infection in HIV patients will go a long way in preventing progression to tumors, which are known to be resistant to treatment. The tumors responded well to X-ray external beam radiotherapy.