AI Article Synopsis
- Disseminated carcinomatosis of the bone marrow is a complex condition caused by prostate cancer metastasizing to the bone marrow, which is often difficult to diagnose through imaging techniques.
- A case study of a 75-year-old man showed that despite treatment and increasing PSA levels, the diagnosis was made using a C-choline PET/CT scan that revealed diffuse uptake in the bone marrow, while a bone scan showed little abnormality.
- The patient's condition was confirmed through a biopsy and, despite starting docetaxel therapy, his PSA levels continued to rise, leading to his death four months after diagnosis, highlighting the aggressive nature of this metastatic cancer.
Article Abstract
Introduction: Disseminated carcinomatosis of the bone marrow is caused by cancer metastasis to the bone marrow and is the diagnosis is very difficult by imaging.
Case Presentation: We report a 75-year-old male with disseminated carcinomatosis of the bone marrow from castration-resistant prostate cancer revealed by C-choline positron emission tomography-computed tomography (PET/CT). Although he already received radiotherapy to the prostate, combined androgen blockade, enzalutamide and apalutamide, and external beam radiotherapy for the pelvic bone metastases, serum prostate-specific antigen (PSA) value rapidly increased from 32 ng/mL to 104 ng/mL in recent 1 month. Bone scintigraphy showed almost no abnormal uptake in the whole body, whereas C-choline PET/CT showed diffuse bone marrow C-choline uptake. The disseminated carcinomatosis of the bone marrow was diagnosed from the discordant findings between bone scintigraphy and C-choline PET/CT examinations and confirmed pathologically by iliac marrow biopsy pathologically. Although docetaxel therapy was started, PSA value continued rising and he died after 4 months of the diagnosis.
Conclusion: The discordant findings of choline PET/CT and bone scintigraphy can diagnose disseminated carcinomatosis of the bone marrow from prostate cancer.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11236384 | PMC |
| http://dx.doi.org/10.1159/000539333 | DOI Listing |
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