Research Progress on the Association between Schizophrenia and Infection.

Biomed Environ Sci

Department of Parasitology, Xiangya School of Basic Medicine, Central South University, Changsha 410013, Hunan, China.

Published: June 2024

( ), is an obligatory intracellular parasite with humans as its intermediate hosts. In recent years, significant correlations between infection and schizophrenia have been reported, including the possible mediating mechanisms. Currently, mechanisms and hypotheses focus on central neurotransmitters, immunity, neuroinflammation, and epigenetics; however, the exact underlying mechanisms remain unclear. In this article, we review the studies related to infection and schizophrenia, particularly the latest research progress. Research on dopamine (DA) and other neurotransmitters, the blood-brain barrier, inflammatory factors, disease heterogeneity, and other confounders is also discussed. In addition, we also summarized the results of some new epidemiological investigations.

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http://dx.doi.org/10.3967/bes2024.071DOI Listing

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