AI Article Synopsis
- Spatial extent (EXT) of amyloid beta (Aβ) in the neocortex may be more effective than traditional Aβ levels for early detection of Alzheimer's disease deposits and understanding their impact on cognitive decline.
- A study using PIB-PET scans from 261 older adults found that EXT could predict cognitive decline and tau proliferation better than Aβ levels alone, revealing that Aβ spreads unevenly across regions of the brain.
- Overall, the findings suggest that measuring Aβ spatial extent could enhance the identification of individuals at risk for Alzheimer's disease, potentially improving intervention strategies in preclinical stages.
Article Abstract
Introduction: Spatial extent-based measures of how far amyloid beta (Aβ) has spread throughout the neocortex may be more sensitive than traditional Aβ-positron emission tomography (PET) measures of Aβ level for detecting early Aβ deposits in preclinical Alzheimer's disease (AD) and improve understanding of Aβ's association with tau proliferation and cognitive decline.
Methods: Pittsburgh Compound-B (PIB)-PET scans from 261 cognitively unimpaired older adults from the Harvard Aging Brain Study were used to measure Aβ level (LVL; neocortical PIB DVR) and spatial extent (EXT), calculated as the proportion of the neocortex that is PIB+.
Results: EXT enabled earlier detection of Aβ deposits longitudinally confirmed to reach a traditional LVL-based threshold for Aβ+ within 5 years. EXT improved prediction of cognitive decline (Preclinical Alzheimer Cognitive Composite) and tau proliferation (flortaucipir-PET) over LVL.
Discussion: These findings indicate EXT may be more sensitive to Aβ's role in preclinical AD than level and improve targeting of individuals for AD prevention trials.
Highlights: Aβ spatial extent (EXT) was measured as the percentage of the neocortex with elevated Pittsburgh Compound-B. Aβ EXT improved detection of Aβ below traditional PET thresholds. Early regional Aβ deposits were spatially heterogeneous. Cognition and tau were more closely tied to Aβ EXT than Aβ level. Neocortical tau onset aligned with reaching widespread neocortical Aβ.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11350060 | PMC |
| http://dx.doi.org/10.1002/alz.14036 | DOI Listing |
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