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IL-17A Mediates Depressive-Like Symptoms by Inducing Microglia Activation in Psoriasiform Dermatitis Mice.
Immun Inflamm Dis
December 2024
Department of Dermatology, Binzhou Medical University Hospital, Binzhou, Shandong, China.
Background: Psoriasis is recognized as a systemic disease for its accompanying comorbidities, among which psychological disorders present a high incidence rate and affect patients' life quality. Interleukin (IL)-17A is the central pathological factor in the pathogenesis and development of psoriasis.
Objective: To clarify if psoriasis-induced systemic IL-17A increase can mediate the neuronal inflammation and result in depressive-like symptoms.
A nanodrug provokes antitumor immune responses via synchronous multicellular regulation for enhanced cancer immunotherapy.
J Colloid Interface Sci
January 2025
College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, China. Electronic address:
Hepatocellular carcinoma (HCC) exhibits a low response to immunotherapy due to the dense extracellular matrix (ECM) filled with immunosuppressive cells including dendritic cells (DCs) of blocked maturation. Herein, we develop a nanoprodrug self-assembled from polyethylene glycol-poly-4-borono-l-phenylalanine (mPEG-PBPA) conjugating with quercetin (QUE) via boronic ester bonds. In addition, an immune adjuvant of imiquimod (R837) is incorporated.
View Article and Find Full Text PDFThe alleviative effects of canagliflozin on imiquimod-induced mouse model of psoriasis-like inflammation.
Naunyn Schmiedebergs Arch Pharmacol
September 2024
College of Pharmacy, Al-Mustaqbal University, Babylon, Hillah, 51001, Iraq.
Psoriasis is a life-long immune-mediated dermatosis with thickened, reddish, and flaky skin patches. Canagliflozin is a gliflozin antidiabetic with non-classical remarkable antioxidative, anti-inflammatory, anti-proliferative, and immune-modulating effects. The aim of this study is to examine the probable effects of topical canagliflozin on a mouse model of imiquimod-provoked psoriasis-like dermatitis.
View Article and Find Full Text PDFCan imiquimod really provoke psoriasis?
Int J Dermatol
August 2024
Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary.
Matrix metalloproteinase landscape in the imiquimod-induced skin inflammation mouse model.
Biochimie
November 2024
LEO Foundation Center for Cutaneous Drug Delivery, Department of Pharmacy, University of Copenhagen, 2100, Copenhagen, Denmark. Electronic address:
Inflammation and autoimmunity are known as central processes in many skin diseases, including psoriasis. It is therefore important to develop pre-clinical models that describe disease-related aspects to enable testing of pharmaceutical drug candidates and formulations. A widely accepted pre-clinical model of psoriasis is the imiquimod (IMQ)-induced skin inflammation mouse model, where topically applied IMQ provokes local skin inflammation.
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