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Evaluating the impact of modeling choices on the performance of integrated genetic and clinical models.
Genet Med
December 2024
Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN; Center for Digital Genomic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN. Electronic address:
Purpose: The value of genetic information for improving the performance of clinical risk prediction models has yielded variable conclusions. Many methodological decisions have the potential to contribute to differential results. We performed multiple modeling experiments integrating clinical and demographic data from electronic health records (EHR) with genetic data to understand which decisions may affect performance.
View Article and Find Full Text PDFSwallowing, speech and voice impairments in head and neck cancer patients treated at a multidisciplinary integrated patient unit.
Int J Lang Commun Disord
December 2024
Hearing, Speech & Language Center, Sheba Medical Center, Tel Hashomer, Israel.
Background: Head and neck cancer (HNC) is amongst the 10 most common cancers worldwide and has a major effect on patients' quality of life. Given the complexity of this unique group of patients, a multidisciplinary team approach is preferable. Amongst the debilitating sequels of HNC and/or its treatment, swallowing, speech and voice impairments are prevalent and require the involvement of speech-language pathologists (SLPs).
View Article and Find Full Text PDFFatigue cracking of rib-to-deck conventional single-sided welded joints is a prevalent issue in orthotropic steel decks (OSDs), significantly impacting their structural integrity and durability. Rib-to-deck innovative double-sided welded joints have the potential to enhance the fatigue resistance of OSD. However, Welding Residual Stresses (WRS) significantly influence the fatigue life of these joints, mandating its consideration in fatigue assessments.
View Article and Find Full Text PDFA novel fuzzy assisted sliding mode control approach for frequency regulation of wind-supported autonomous microgrid.
Sci Rep
December 2024
Department of Electrical and Electronics Engineering, SR University, Warangal, Telangana, 506371, India.
Autonomous microgrids (ATMG), with green power sources, like solar and wind, require an efficient control scheme to secure frequency stability. The weather and locationally dependent behavior of the green power sources impact the system frequency imperfectly. This paper develops an intelligent, i.
View Article and Find Full Text PDFStrategic model for integrating biogas a framework for sustainable energy integration in agro-industries.
Sci Rep
December 2024
Industrial and Systems Engineering Department, Institut Teknologi Sepuluh Nopember, Surabaya, Indonesia.
The framework of the methodology presented in this study is an effort to integrate and optimize the agro-industry sector, especially energy in biogas. In this study, the technique of the system in functional analysis is shown systematically to translate various energy requirements in the factory as criteria for performance and functional design to be integrated, optimized, and energy efficient. The case study results indicated that biogas power plants, with a capacity of 1.
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