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Variation of gene ratios in mock communities constructed with purified 16S rRNA during processing.
Sci Rep
December 2024
Department of Chemical Engineering, Polytechnic School, University of São Paulo, Av. Prof. Luciano Gualberto, Travessa 3, n. 380., São Paulo, SP, CEP 05508-900, Brazil.
16S ribosomal nucleic acid (16S rRNA) analysis allows to specifically target the metabolically active members of microbial communities. The stability of the ratios between target genes in the workflow, which is essential for the bioprocess-relevance of the data derived from this analysis, was investigated using synthetic mock communities constructed by mixing purified 16S rRNA from Bacillus subtilis (Bs), Staphylococcus aureus (Sa), Pseudomonas aeruginosa (Pa), Klebsiella pneumoniae (Kp) and Burkholderia cepacia (Bc) in different proportions. The RT reaction yielded one copy of cDNA per rRNA molecule for Pa, Bc and Sa but only 2/3 of the expected cDNA from 16S rRNAs of Bs and Kp.
View Article and Find Full Text PDFA coopetition-driven strategy of parallel/perpendicular aromatic stacking enabling metastable supramolecular polymerization.
Nat Commun
December 2024
School of Chemistry and Chemical Engineering, Northwestern Polytechnical University, Xi'an, 710072, China.
Metastable supramolecular polymerization under kinetic control has recently been recognized as a closer way to biosystem than thermodynamic process. While impressive works on metastable supramolecular systems have been reported, the library of available non-covalent driving modes is still small and a simple yet versatile solution is highly desirable to design for easily regulating the energy landscapes of metastable aggregation. Herein, we propose a coopetition-driven metastability strategy for parallel/perpendicular aromatic stacking to construct metastable supramolecular polymers derived from a class of simple monomers consisting of lateral indoles and aromatic core.
View Article and Find Full Text PDFA Functional Response in Resource Selection Links Multiscale Responses of a Large Carnivore to Human Mortality Risk.
Ecol Lett
January 2025
School of Natural Resources, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
Theory suggests that animals make hierarchical, multiscale resource selection decisions to address the hierarchy of factors limiting their fitness. Ecologists have developed tools to link population-level resource selection across scales; yet, theoretical expectations about the relationship between coarse- and fine-scale selection decisions at the individual level remain elusive despite their importance to fitness. With GPS-telemetry data collected across California, USA, we evaluated resource selection of mountain lions (Puma concolor; n = 244) relative to spatial variation in human-caused mortality risk.
View Article and Find Full Text PDFExploring the relationships between complex post-traumatic stress disorder and depression symptoms in the context of childhood maltreatment through network analysis.
Child Abuse Negl
December 2024
Beijing Key Laboratory of Applied Experimental Psychology, National Demonstration Center for Experimental Psychology Education (Beijing Normal University), Faculty of Psychology, Beijing Normal University, Beijing 100875, China.
Background: Individuals with a history of childhood maltreatment commonly experience the co-occurrence of complex post-traumatic stress disorder (CPTSD) and depression, but the underlying mechanisms of their comorbidities remain unclear.
Methods: We recruited 2740 college students, including 1366 who experienced childhood maltreatment to assess the co-occurrence network of CPTSD and depression symptoms. We constructed a Gaussian graphical model to visualize the associations between symptoms and a directed acyclic graph to explore inferred relationships among symptoms.
Biomimetic intelligent nanoplatform with cascade amplification effect for tumor synergy therapy.
Sci Rep
December 2024
Department of Clinical Laboratory, The Affiliated People's Hospital of Jiangsu University, Zhenjiang, 212002, Jiangsu, China.
Tumor heterogeneity, immune-suppressive microenvironment and the precise killing of tumor cells by drugs are important factors affecting tumor treatment. In this study, we developed environment-responsive drug delivery system (FM@IQ/PST&ZIF-8/DOX) based on ZIF-8 for tumor photothermal/immunotherapy/chemotherapy synergistic therapy. The prepared FM@IQ/PST&ZIF-8/DOX nanoplatfrom not only has highly drug loading capacity for chemotherapeutic drug-doxorubicin, but also erythrocyte membrance modified on their surface can endow their immunity-escaping property and prolong their blood circulation time.
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