Recently, the incidence of heat-related illnesses has exhibited a steadily upward trend, which is closely associated with several environmental factors such as climate change and air pollution. The progression of heat-related illnesses is a continuous process and can progress to the terminal period when it transforms into heat stroke, the most severe form. Heat stroke is markedly by a core body temperature above 40°C and central nervous system dysfunction. Current knowledge suggests that the pathogenesis of heat stroke is complex and varied, including inflammatory response, oxidative stress, cell death, and coagulation dysfunction. This review consolidated recent research progress on the pathophysiology and pathogenesis of heat stroke, with a focus on the related molecular mechanisms. In addition, we reviewed common strategies and sorted out the drugs in various preclinical stages for heat stroke, aiming to offer a comprehensive research roadmap for more in-depth researches into the mechanisms of heat stroke and the reduction in the mortality of heat stroke in the future.
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http://dx.doi.org/10.1016/j.arr.2024.102409 | DOI Listing |
Ecotoxicol Environ Saf
December 2024
Spinal surgery, China-Japan Friendship Hospital, East Ying Hua Yuan Street, Chaoyang District, Beijing, China.
Heatstroke (HS) is gradually becoming a major challenge in the field of global public health with the trend of global warming. In recent years, extreme high-temperature weather events have occurred frequently in the world, which directly led to a significant increase in heatstroke. However, up to now, the potential pathological effects of HS on articular cartilage have not been revealed.
View Article and Find Full Text PDFFront Cell Infect Microbiol
December 2024
Department of Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
This retrospective multicenter study was conducted across 83 intensive care units (ICUs) in 16 cities in Sichuan, China. Critically ill patients diagnosed with heatstroke and lung infections were included in the study. Specimens from the lower respiratory tract were collected for microbiological testing, and the characteristics of the pathogens were described.
View Article and Find Full Text PDFSports Health
December 2024
Korey Stringer Institute, Department of Kinesiology, University of Connecticut, Storrs, Connecticut.
Background: Exertional heat stroke (EHS) is a leading cause of secondary school sport-related death; however, a longitudinal analysis on observed trends is lacking. Our purpose was to describe EHS deaths in United States secondary school athletes since the 1982/1983 academic year.
Hypothesis: EHS deaths will be primarily represented by football athletes and have a stable or increasing trend across a decade-by-decade analysis.
Pain
September 2024
Molecular, Cellular and Biochemical Pharmacology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Early life stress (ELS) is associated with an increased risk of experiencing chronic pain during adulthood, but surprisingly little is known about the short-term influence of ELS on nociceptive processing in the immature nervous system and the concomitant effects on somatosensation in the neonate. Here, we investigate how ELS modulates pain in neonatal mice and the transcriptional and electrophysiological signatures of immature dorsal root ganglia (DRG). Shortly after the administration of a neonatal limiting bedding (NLB) paradigm from postnatal days (P)2 to P9, both male and female pups exhibited robust hypersensitivity in response to tactile, pressure, and noxious cold stimuli compared with a control group housed under standard conditions, with no change in their sensitivity to noxious heat.
View Article and Find Full Text PDFFront Cardiovasc Med
November 2024
Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Department of Anesthesiology and Intensive Care Medicine, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Berlin, Germany.
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