AI Article Synopsis
- * Indoles, a class of compounds, play a key role in bacterial behaviors linked to antibiotic resistance, including biofilm formation and drug stability.
- * Recent research highlights the potential of indole hybrids as effective antibacterial agents against both sensitive and resistant strains of A. baumannii, suggesting new pathways for developing treatments to combat these infections.
Article Abstract
Acinetobacter baumannii with the capability to "escape" almost all currently available antibacterials is eroding the safety of basic medical interventions and is an increasing cause of mortality globally, prompting a substantial requirement for new classes of antibacterial agents. Indoles participate in the regulation of persistent bacterial formation, biofilm formation, plasmid stability, and drug resistance. In particular, indole hybrids demonstrated promising antibacterial activity against both drug-sensitive and drug-resistant A. baumannii pathogens, representing a fertile source for the discovery of novel therapeutic agents for clinical deployment in controlling A. baumannii infections. This mini-review outlines the current innovations of indole hybrids with antibacterial activity against A. baumannii pathogens, covering articles published from 2020 to the present, to open new avenues for exploring novel anti-A. baumannii candidates.
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| http://dx.doi.org/10.1002/ardp.202400440 | DOI Listing |
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