AI Article Synopsis
- Epithelial cells play a crucial role in immune responses against fungal infections, particularly in the lungs and mucosal surfaces.
- They respond to certain signals like IL-1 and interferon to manage immune cell activity and fungal destruction.
- Understanding how these cells interact with fungi is essential for developing new treatments for fungal infections.
Article Abstract
Epithelial cells orchestrate immune responses against fungal pathogens. This review highlights advances in integrating epithelial cells in immune responses against inhaled molds and dimorphic fungi, and against Candida species that colonize mucosal surfaces. In the lung, epithelial cells respond to interleukin-1 (IL-1) and interferon signaling to regulate effector cell influx and fungal killing. In the alimentary and vulvovaginal tracts, epithelial cells modulate fungal commensalism, invasive growth, and local immune tone, in part by responding to damage caused by candidalysin, a C. albicans peptide toxin, and through IL-17-dependent release of antimicrobial peptides that contribute to Candida colonization resistance. Understanding fungal-epithelial interactions in mammalian models of disease is critical to predict vulnerabilities and to identify opportunities for immune-based strategies to treat fungal infections.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11331878 | PMC |
| http://dx.doi.org/10.1016/j.mib.2024.102508 | DOI Listing |
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