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Evaluation of three rapid assays for detecting Mycoplasma pneumoniae in nasopharyngeal specimens.
AMB Express
December 2024
Department of Clinical Laboratory, Peking Union Medical College Hospital, No.1 Shuaifuyuan Wangfujing Dongcheng District, Beijing, 100730, China.
During the 2023 autumn-winter period in China, Mycoplasma pneumoniae (MP) infections have increased. To address this, rapid and accurate MP DNA detection methods are crucial. Three nucleic acid detection assays (Ustar, Coyote Flash10, Coyote Flash 20) that are widely used in China are currently being evaluated for their effectiveness in detecting MP DNA in nasopharyngeal specimens.
View Article and Find Full Text PDFUsing multiplexed functional data to reduce variant classification inequities in underrepresented populations.
Genome Med
December 2024
Human Genomics and Evolution, St Vincent's Institute of Medical Research, Fitzroy, 3065, Australia.
Background: Multiplexed Assays of Variant Effects (MAVEs) can test all possible single variants in a gene of interest. The resulting saturation-style functional data may help resolve variant classification disparities between populations, especially for Variants of Uncertain Significance (VUS).
Methods: We analyzed clinical significance classifications in 213,663 individuals of European-like genetic ancestry versus 206,975 individuals of non-European-like genetic ancestry from All of Us and the Genome Aggregation Database.
Survey for spp. in wildlife in the eastern United States.
Int J Parasitol Parasites Wildl
December 2024
Department of Biomedical and Diagnostic Sciences, University of Tennessee College of Veterinary Medicine, Knoxville, TN, USA.
is a diverse genus of piroplasms that parasitize the red blood cells of a wide variety of mammals and avian species, including humans. There is a lack of knowledge on the species of carnivores and mesomammals in the eastern United States and the potential impacts of these species on the health of humans and domestic animals. We surveyed 786 wild mammals in the eastern United States by testing blood, spleen, and heart samples with PCR targeting the 18S rRNA region of apicomplexan parasites.
View Article and Find Full Text PDFInfluence of COVID-19 pandemic on prevalence and genotype distribution of HPV in cervical cancer screening population.
Virol J
October 2024
Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Background: Human Papillomavirus (HPV) DNA screening was a crucial element in the fight against cervical cancer and had been adopted in many countries, including China. However, the onset of the COVID-19 pandemic in March 2020 disrupted this program significantly.
Methods: The aim of this study is to investigate the prevalence and distribution of HPV genotypes among the population undergoing cervical cancer screening during the pandemic period.
The Coyote Clinic: A Student-Run Free-Clinic.
S D Med
February 2024
Sanford USD Medical Center, Sioux Falls, South Dakota.
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