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Getah virus Nsp3 binds G3BP to block formation of bona fide stress granules.
Int J Biol Macromol
November 2024
Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China; Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou 225009, China. Electronic address:
Stress granules (SGs) are cytoplasmic aggregates of proteins and mRNA that form in response to diverse environmental stressors, including viral infections. Several viruses possess the ability to block the formation of stress granules by targeting the SGs marker protein G3BP. However, the molecular functions and mechanisms underlying the regulation of SGs formation by Getah virus (GETV) remain unclear.
View Article and Find Full Text PDFThe divergent effects of G3BP orthologs on human stress granule assembly imply a centric role for the core protein interaction network.
Cell Rep
August 2024
Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China; School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China. Electronic address:
Liquid-liquid phase separation (LLPS) mediated by G3BP1/2 proteins and non-translating mRNAs mediates stress granule (SG) assembly. We investigated the phylogenetic evolution of G3BP orthologs from unicellular yeast to mammals and identified both conserved and divergent features. The modular domain organization of G3BP orthologs is generally conserved.
View Article and Find Full Text PDFStress granules in atherosclerosis: Insights and therapeutic opportunities.
Curr Probl Cardiol
October 2024
Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400030, China. Electronic address:
Atherosclerosis, a complex inflammatory and metabolic disorder, is the underlying cause of several life-threatening cardiovascular diseases. Stress granules (SG) are biomolecular condensates composed of proteins and mRNA that form in response to stress. Recent studies suggest a potential link between SG and atherosclerosis development.
View Article and Find Full Text PDFUBAP2L contributes to formation of P-bodies and modulates their association with stress granules.
J Cell Biol
October 2024
Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Boston, MA, USA.
Stress triggers the formation of two distinct cytoplasmic biomolecular condensates: stress granules (SGs) and processing bodies (PBs), both of which may contribute to stress-responsive translation regulation. Though PBs can be present constitutively, stress can increase their number and size and lead to their interaction with stress-induced SGs. The mechanism of such interaction, however, is largely unknown.
View Article and Find Full Text PDF[Role of G3BP proteins in SARS-CoV-2 replication].
Med Sci (Paris)
July 2024
Université Paris Cité, CNRS UMR8104, Inserm U1016, Institut Cochin, équipe Interactions hôte-virus, Paris, France.
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