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Knowledge, attitudes, and practices (KAP) of animal health staff and farmers towards brucellosis control in sheep and goat in China: A cross-sectional study.
PLoS One
January 2025
Faculty of Veterinary Science, Department of Veterinary Public Health, Chulalongkorn University, Bangkok, Thailand.
Background: In China, brucellosis has resurfaced recently with a discernible spatial distribution, particularly affecting dairy herds and small ruminant populations. However, limited dissemination of knowledge, attitudes, and practices (KAP) for brucellosis control exists among farmers and animal health staff. This study aimed to assess the KAP of brucellosis control and prevention in animal health staff and farmers, with the goal of educating the public regarding the application of efficient brucellosis control and prevention strategies.
View Article and Find Full Text PDFBarriers and facilitators of community-based nursing development: A scoping review.
J Educ Health Promot
December 2024
Nursing and Midwifery Care Research Canter (NMCRC), School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran.
In the last few decades, chronic diseases have spread and new and emerging health and social issues have affected people's health. COVID-19 and other emerging and re-emerging diseases are creating new challenges for societies that affect how healthcare is managed. It is through the development of community-based nursing that some of these problems can be solved.
View Article and Find Full Text PDFChronic inflammation in post-acute sequelae of COVID-19 modulates gut microbiome: a review of literature on COVID-19 sequelae and gut dysbiosis.
Mol Med
January 2025
Center for Emerging and Re-emerging Infectious Diseases (CERID), University of Washington, Seattle, USA.
Background: Long COVID or Post-acute sequelae of COVID-19 is an emerging syndrome, recognized in COVID-19 patients who suffer from mild to severe illness and do not recover completely. Most studies define Long COVID, through symptoms like fatigue, brain fog, joint pain, and headache prevailing four or more weeks post-initial infection. Global variations in Long COVID presentation and symptoms make it challenging to standardize features of Long COVID.
View Article and Find Full Text PDFMolecular modelling and optimization of a high-affinity nanobody targeting the nipah virus fusion protein through in silico site-directed mutagenesis.
Comput Biol Chem
January 2025
Virology and Vaccine Research and Development Program, Department of Science and Technology-Industrial Technology Development Institute, Taguig City, Metro Manila 1631, Philippines; S&T Fellows Program, Department of Science and Technology, Taguig City, Metro Manila 1631, Philippines; Department of Biology, College of Arts and Sciences, University of the Philippines - Manila, Metro Manila 1000, Philippines. Electronic address:
Nipah virus (NiV) is a re-emerging zoonotic pathogen with a high mortality rate and no effective treatments, prompting the search for new antiviral strategies. While conventional antiviral drugs are often limited by issues such as poor specificity, off-target effects, and resistance development, nanobodies offer distinct advantages. These small, single-domain antibodies exhibit high specificity and stability, making them ideal candidates for antiviral therapy.
View Article and Find Full Text PDFEvolution of parasite transmission dispersion.
R Soc Open Sci
January 2025
Institute for Integrative Biology, ETH Zürich, 8005 Zürich, Switzerland.
An open question in epidemiology is why transmission is often overdispersed, meaning that most new infections are driven by few infected individuals. For example, around 10% of COVID-19 cases cause 80% of new COVID-19 cases. This overdispersion in parasite transmission is likely driven by intrinsic heterogeneity among hosts, i.
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