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Intense Pulsed Light in the Treatment of Dry Eye and Meibomian Gland Dysfunction in Patients With Chronic Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.
Cornea
January 2025
Department of Ophthalmology and Visual Sciences, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Purpose: To evaluate the efficacy and safety of intense pulsed light (IPL) combined with meibomian gland expression (MGX) for the treatment of dry eye disease and meibomian gland dysfunction associated with chronic Stevens-Johnson syndrome and toxic epidermal necrolysis.
Methods: This prospective noncomparative interventional study included 29 patients (58 eyes) who underwent 3 sessions of IPL and MGX at 2-week intervals. Subjective symptoms (ocular surface disease index score) and objective dry eye tests: matrix metalloproteinase 9, tear meniscus height, bulbar redness score, tear film lipid layer thickness (LLT), Schirmer I test, conjunctival and corneal staining, meibomian gland loss, MGX score [meibomian gland score (MGS)], and tear break-up time were assessed at the baseline and after 4, 8, and 12 weeks.
Regulation of innate immune response by miRNAs up-regulated in Stevens-Johnson syndrome with severe ocular complications.
Sci Rep
January 2025
Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajiicho, Hirokoji, Kawaramachi, Kamigyoku, Kyoto, 602-0841, Japan.
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe mucocutaneous disorders characterized by extensive tissue necrosis; they are often accompanied by severe ocular complications (SOC). The regulatory role of microRNAs (miRNAs) in modulating immune responses in SJS/TEN is not fully understood, particularly in relation to chronic SOC. We explored the expression profiles of specific miRNAs and their potential impact on the regulation of key innate immune genes in patients with SJS/TEN with SOC.
View Article and Find Full Text PDFAcquired Ankyloblepharon Correction Using Ocular Surface and Tarsal Mucous Membrane Grafting in Cicatrizing Ocular Surface Diseases.
Ophthalmic Plast Reconstr Surg
January 2025
Hariram Motumal Nasta & Renu Hariram Nasta Ophthalmic Plastic Surgery Services.
Purpose: To report the long-term surgical outcomes of acquired ankyloblepharon correction using mucous membrane graft.
Methods: Five eyes of 4 patients (median age, 19 years) with acquired ankyloblepharon were managed using eyelid splitting and mucous membrane graft anchored to the recti muscles on the bulbar surface in the respective quadrant and onto the bare tarsal surface. Outcome measures include a change in the palpebral fissure width, ability to fit scleral contact lenses, visual acuity, and cosmesis.
Severe Cutaneous Toxicity in A 67-Year-Old Patient with Metastatic Urothelial Carcinoma Undergoing Therapy with Enfortumab Vedotin and Pembrolizumab.
Eur J Case Rep Intern Med
November 2024
Department of Oncology, Cantonal Hospital Baselland, Liestal, Switzerland.
Article Synopsis
- Enfortumab vedotin combined with pembrolizumab (EV+P) shows effectiveness in treating metastatic urothelial carcinoma, but can lead to severe skin reactions like Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN).
- A case is presented of a 67-year-old man who developed SJS/TEN overlap after EV+P therapy, demonstrating the importance of recognizing and treating severe skin toxicities early in patients with additional health issues.
- Effective management requires quick action with steroids and a multidisciplinary approach, alongside vigilant monitoring and reporting of adverse effects to enhance patient safety.
A case report of Stevens-Johnson syndrome caused by omeprazole.
Medicine (Baltimore)
September 2024
Department of Gastroenterology, Shaanxi Provincial People's Hospital, Xi'an, China.
Article Synopsis
- Stevens-Johnson syndrome (SJS) is a serious condition marked by painful skin and mucosal blistering, often leading to significant complications like pneumonia and organ failure.
- A 51-year-old woman developed SJS after taking omeprazole, which resulted in worsening liver function and chronic acute liver failure.
- After stopping the suspected medication and administering supportive treatments, the patient's rash resolved and her liver and kidney functions improved significantly, highlighting the need for understanding drug-induced SJS in patients with liver conditions.
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