Objectives: The migrant community of the Shipibo-Konibo indigenous people in Lima, Peru were extremely vulnerable during the COVID-19 pandemic. Additionally, infection with human T-cell lymphotropic virus type 1 and 2 (HTLV-1/2) is endemic in this population causing immunosuppression. The aim of the study was to describe the association between HTLV-1/2 infection and the clinical severity of COVID-19.
Methods: This was a cross-sectional descriptive study involving a survey of adult Shipibo-Konibo indigenous migrants residing in Cantagallo-Rímac who were identified as suspected or confirmed cases of COVID-19. Blood samples were collected for SARS-CoV-2 antibody and HTLV-1/2 ELISA testing. A confirmatory Western Blot test was performed for those with a positive ELISA test.
Results: A total of 182 individuals were surveyed and sampled. No significant association was found between HTLV-1/2 infection and the clinical severity of COVID-19. The prevalence of HTLV-1/2 was 8.8% (95%CI: 5.0-14.1) with Western Blot. Age was the only statistically significant risk factor for developing a more severe form of COVID-19 (OR: 1.03; 95%CI: 1.00-1.06; p = 0.032).
Conclusions: There was no association found between HTLV-1/2 infection and the clinical severity of COVID-19. The prevalence of HTLV-1/2 infection in the Shipibo-Konibo population is high and warrants continuous monitoring in the advent of other infectious disease outbreaks and the development of HTLV-associated comorbidities.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11236200 | PMC |
| http://dx.doi.org/10.1371/journal.pgph.0003442 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Human T-lymphotropic Virus infection among Quilombo communities in Central Brazil.
Trans R Soc Trop Med Hyg
December 2024
Univer sidade Federal de Mato Grosso do Sul, Laboratório de Imunologia Clínica, Campo Grande 79070-900, Mato Grosso do Sul, Brazil.
Background: This study estimated the sociodemographic characteristics and prevalence of Human T-lymphotropic Virus (HTLV) infection among Afro-Brazilians in the two largest remnant Quilombo communities in Mato Grosso do Sul State.
Methods: Participants were interviewed from October 2015 to October 2016. Blood samples were collected and screened for anti-HTLV-1/2 antibodies using a commercial ELISA kit.
First report on human T-lymphotropic virus 1 infection in a group of transgender women.
Front Public Health
November 2024
Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, Brazil.
Article Synopsis
- A study was conducted to determine the prevalence of HTLV-1 infection among transgender women (TGW) in Goiânia City, Brazil, revealing a knowledge gap in existing data on this demographic.
- From a sample of 235 TGW, 1.3% tested positive for HTLV-1, with those positive reporting high-risk sexual behaviors and drug use.
- The findings highlight the urgent need for health programs aimed at TGW to control HTLV-1 and other sexually transmitted infections due to their high-risk behaviors.
HTLV infection in urban population from Mato Grosso do Sul, Central Brazil.
Retrovirology
November 2024
Universidade Federal de Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
Background: Brazil has the highest number of HTLV-1 infection in Latin America, with around one million cases spread unevenly across regions. However, there is a limited number of studies on this infection in the general population. This cross-sectional study aimed to estimate the prevalence of HTLV as well as identify types, and subtypes of HTLV among the urban population of Campo Grande, capital of Mato Grosso do Sul state (MS).
View Article and Find Full Text PDFIntrafamilial Transmission of HTLV-1 and HTLV-2 in Indigenous Peoples of the Brazilian Amazon: Molecular Characterization and Phylogenetic Analysis.
Viruses
September 2024
Laboratório de Virologia, Universidade Federal do Pará, Belém 66075-110, Brazil.
Human T-limphotropic virus 1 infection has a global distribution, with a high prevalence in some regions of Brazil and the world, while HTLV-2 infection is endemic mainly among indigenous people and drug users. To analyze intrafamilial transmission of HTLV-1/2 in five Kayapó indigenous peoples (Gorotire, Kararaô, Kokraimoro, Kubenkokre, and Xikrin do Bacajá), we investigated 1452 individuals who underwent serological and molecular tests. Among the 276 indigenous people with positive results, we identified intrafamily transmission in 42.
View Article and Find Full Text PDFLow-cost and simple PCR process for access to molecular diagnosis of HTLV-1/2 in low-resource countries.
Acta Trop
December 2024
Facultad de Farmacia y Bioquímica, Departamento de Microbiología, Inmunología y Biotecnología, Centro de Referencia en Identificación Genética Humana (CRIGH), Servicio de Huellas Digitales Genéticas (SHDG) y Cátedra de Genética Forense, Universidad de Buenos Aires, Buenos Aires, Argentina. CONICET, Buenos Aires, Argentina. Electronic address:
Background: HTLV-1/2 exhibit a widespread distribution globally and are associated with severe clinical manifestations, necessitating precise viral identification for diagnosis. Currently, there are no official diagnostic guidelines, and a variety of published protocols exists. We introduce an enhanced nested real-time PCR technique followed by high-resolution melting (rtPCR-HRM), designed to offer a cost-effective and straightforward tool for the simultaneous identification of both viruses.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!