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Disruption of tumor-intrinsic PGAM5 increases anti-PD-1 efficacy through the CCL2 signaling pathway.
J Immunother Cancer
January 2025
Department of Radiation Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China
Background: Immunosuppressive phenotype compromised immunotherapy efficacy of hepatocellular carcinoma. Tumor cells intrinsic mitochondria dynamics could pass effects on the extracellular microenvironment through mtDNA stress. PGAM5 anchors at mitochondria and regulates mitochondria functions.
View Article and Find Full Text PDFExploring postpartum women's experiences, perspectives, and expectations in maternal health care at a Chinese maternity care center: a qualitative study.
BMC Pregnancy Childbirth
January 2025
Academic Center for General Practice, Department of Public Health and Primary Care, Leuven, KU, Belgium.
Background: The postpartum period presents critical challenges for new mothers, involving significant physical and emotional adjustments. Traditionally, Chinese culture has addressed this phase through "doing the month," emphasizing rest and specific cultural practices. Modernization in urban China has led to a rise in professional maternal care centers, yet research on women's experiences and expectations in these settings remains limited.
View Article and Find Full Text PDFDirectional and Strain-Specific Interaction Between and .
Microorganisms
November 2024
Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA.
The interaction between and strains FRI-1169 and MN8, two original isolated strains from menstrual toxic shock syndrome (mTSS) cases, is a key focus for developing non-antibiotic strategies to control -related infections. While the antagonistic effects of species on through mechanisms like organic acid and bacteriocin production are known, the molecular dynamics of these interactions remain underexplored. This study employs a proteomic approach to analyze the interactions between WCFS1 and strains, FRI-1169 and MN8, during co-culture.
View Article and Find Full Text PDFModeling Fibroblast-Cardiomyocyte Interactions: Unveiling the Role of Ion Currents in Action Potential Modulation.
Int J Mol Sci
December 2024
Bioinspired Engineering and Biomechanics Center, Xi'an Jiaotong University, Xi'an 710049, China.
Fibrotic cardiomyopathy represents a significant pathological condition characterized by the interaction between cardiomyocytes and fibroblasts in the heart, and it currently lacks an effective cure. In vitro platforms, such as engineered heart tissue (EHT) developed through the co-culturing of cardiomyocytes and fibroblasts, are under investigation to elucidate and manipulate these cellular interactions. We present the first integration of mathematical electrophysiological models that encapsulate fibroblast-cardiomyocyte interactions with experimental EHT studies to identify and modulate the ion channels governing these dynamics.
View Article and Find Full Text PDFKeratinocyte-Mediated Antigen Presentation in Psoriasis: Preliminary Insights from In Vitro Studies.
Int J Mol Sci
December 2024
Department of Medical Biology and Genetics, University of Gdansk, Wita Stwosza 59, 80-308 Gdansk, Poland.
Antigen presentation plays a critical role in the pathogenesis of immune-mediated disorders. This study aimed to investigate the effects of IFN-γ and a cytokine mix (5MIX: IL-1α, IL-17A, IL-22, OsM, and TNF-α) on the antigen-presenting capabilities of keratinocytes, with a specific focus on immune-mediated dermatological conditions such as psoriasis (Ps). To achieve this, keratinocytes were treated with IFN-γ and 5MIX, and their impact on the expression of key antigen-presentation molecules, HLA-DRα and CD74, was assessed.
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