We developed a new transient directing group, -(2-benzoyl-4-chlorophenyl)-1,1,1-trifluoromethanesulfonamide, which can facilitate the γ-monoarylation of free amines containing symmetric γ-C-H bonds. A variety of amines containing symmetric and identical γ-C(sp)-H and γ-C(sp)-H reacted with a diverse range of aryl and heteroaryl iodides to provide γ-monoarylated products exclusively.
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| http://dx.doi.org/10.1021/acs.orglett.4c01968 | DOI Listing |
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