AI Article Synopsis
- In rare cases, patients who are intoxicated may need extracorporeal procedures to help remove toxins from their bodies more effectively.
- The EXTRIP workgroup provides updated guidelines based on evidence and consensus for using these procedures in critically ill, poisoned patients.
- The best results for toxin removal occur with substances that have specific properties, and intermittent hemodialysis is the most effective method, while continuous procedures are better for patients with compromised blood flow.
Article Abstract
In rare cases, intoxicated patients may require an extracorporeal procedure for enhanced toxin elimination. The Extracorporeal Treatments in Poisoning (EXTRIP) workgroup provides consensus- and evidence-based recommendations regarding the use of extracorporeal procedures in the management of critically ill, poisoned patients, with ongoing updates. Extracorporeal clearance is highest for low molecular weight substances with low volume of distribution, low plasma protein binding, and high water-solubility. To maximize the effect of extracorporeal clearance, blood and dialysate flow rates should be as high as possible, and the membrane with the largest surface area should be utilized. Intermittent hemodialysis is the most commonly employed extracorporeal procedure due to its highest effectiveness, while hemodynamically compromised patients can benefit from a continuous procedure.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11405442 | PMC |
| http://dx.doi.org/10.1007/s00063-024-01156-6 | DOI Listing |
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