AI Article Synopsis
- - The study investigates the effects of sea cucumber phospholipids on obesity-associated glomerulopathy (ORG) in mice, linking it to high-fat diets and lipid metabolism issues
- - Two specific phospholipids, plasmalogen (PlsEtn) and plasmanylcholine (PakCho), were found to significantly influence the levels of phospholipids in mouse kidneys, with PlsEtn being more effective
- - The findings suggest that sea cucumber phospholipids help reduce lipid buildup in the kidneys, protect against kidney damage, and improve the overall balance of kidney phospholipids, thereby countering the effects of ORG.
Article Abstract
Sea cucumber phospholipids have ameliorative effects on various diseases related to lipid metabolism. However, it is unclear whether it can ameliorate obesity-associated glomerulopathy (ORG) induced by a high-fat diet (HFD). The present study applied UPLC-QqQ-MS/MS and atmospheric pressure matrix-assisted laser desorption ionization mass spectrometry imaging (AP-MALDI MSI) to investigate the effects of sea cucumber phospholipids, including plasmalogen PlsEtn and plasmanylcholine PakCho, on phospholipid profiles in the HFD-induced ORG mouse kidney. Quantitative analysis of 135 phospholipids revealed that PlsEtn and PakCho significantly modulated phospholipid levels. Notably, PlsEtn modulated kidney overall phospholipids better than PakCho. Imaging the "space-content" of 9 phospholipids indicated that HFD significantly increased phospholipid content within the renal cortex. Furthermore, PlsEtn and PakCho significantly decreased the expression of transport-related proteins CD36, while elevating the expression of fatty acid β-oxidation-related protein PPAR-α in the renal cortex. In conclusion, sea cucumber phospholipids reduced renal lipid accumulation, ameliorated renal damage, effectively regulated the content and distribution of renal phospholipids, and improved phospholipid homeostasis, exerting an anti-OGR effect.
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| http://dx.doi.org/10.1021/acs.jafc.4c02692 | DOI Listing |
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