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Injectable vancomycin-loaded silk fibroin/methylcellulose containing calcium phosphate-based in situ thermosensitive hydrogel for local treatment of osteomyelitis: Fabrication, characterization, and in vitro performance evaluation. | LitMetric

AI Article Synopsis

  • The study addresses the limitations of conventional osteomyelitis treatment using antibiotic-loaded PMMA beads by developing an injectable hydrogel (VC-SF/MC-CAPs) that contains vancomycin and promotes better bone reconstruction.
  • The hydrogel can be injected easily, transforms into a rigid state at body temperature, and maintains a high vancomycin content, allowing for effective drug release over time.
  • After testing, the VC-SF/MC-CAPs showed prolonged antibacterial activity against Staphylococcus aureus, while also degrading to support bone formation, indicating its potential as a local treatment for osteomyelitis.

Article Abstract

The conventional treatment of osteomyelitis with antibiotic-loaded nondegradable polymethylmethacrylate (ATB-PMMA) beads has certain limitations, including impeded bone reconstruction and the need for secondary surgery. To overcome this challenge, this study aimed to develop and characterize an injectable vancomycin-loaded silk fibroin/methylcellulose containing calcium phosphate-based in situ thermosensitive hydrogel (VC-SF/MC-CAPs). The VC-SF/MC-CAPs solution can be easily administered at room temperature with a low injectability force of ≤30 N and a high vancomycin (VC) content of ~96%. Additionally, at physiological temperature (37 °C), the solution could transform into a rigid hydrogel within 7 minutes. In vitro drug release performed under both physiological (pH 7.4) and infection conditions (pH 4.5) revealed a prolonged release pattern of VC-SF/MC-CAPs following the Peppas-Sahlin kinetic model. In addition, the released VC from VC-SF/MC-CAPs hydrogels exhibited antibacterial activity against Staphylococcus aureus for a period exceeding 35 days, as characterized by the disk diffusion assay. Furthermore, at pH 7.4, the VC-SF/MC-CAPs demonstrated >60% degradation within 35 days. Importantly, when exposed to physiological pH conditions, CAPs are transformed into bioactive hydroxyapatite, which benefits bone formation. Therefore, VC-SF/MC-CAPs showed significant potential as a local drug delivery system for treating osteomyelitis.

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Source
http://dx.doi.org/10.1002/jbm.a.37772DOI Listing

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