AI Article Synopsis

  • - ICU-acquired weakness (ICU-AW) is a syndrome causing generalized weakness in critically ill patients, identified by a lack of other causes and associated with factors like hyperglycemia, sedatives, and prolonged mechanical ventilation.
  • - Key risk factors for ICU-AW include older age, female sex, pre-existing health conditions, and the severity of illness, but the relationship between longer ICU stays and ICU-AW isn’t easily modified for prevention.
  • - Research suggests that to prevent ICU-AW more effectively, new strategies should focus on identified risk factors rather than just the duration of ICU care, and multicentric randomized controlled trials could help clarify these influences.

Article Abstract

Intensive care unit-acquired weakness (ICU-AW; ICD-10 Code: G72.81) is a syndrome of generalized weakness described as clinically detectable weakness in critically ill patients with no other credible cause. The risk factors for ICU-AW include hyperglycemia, parenteral nutrition, vasoactive drugs, neuromuscular blocking agents, corticosteroids, sedatives, some antibiotics, immobilization, the disease severity, septicemia and systemic inflammatory response syndrome, multiorgan failure, prolonged mechanical ventilation (MV), high lactate levels, older age, female sex, and pre-existing systemic morbidities. There is a definite association between the duration of ICU stay and MV with ICU-AW. However, the interpretation that these are modifiable risk factors influencing ICU-AW, appears to be flawed, because the relationship between longer ICU stays and MV with ICU-AW is reciprocal and cannot yield clinically meaningful strategies for the prevention of ICU-AW. Prevention strategies must be based on other risk factors. Large multicentric randomized controlled trials as well as meta-analysis of such studies can be a more useful approach towards determining the influence of these risk factors on the occurrence of ICU-AW in different populations.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11229901PMC
http://dx.doi.org/10.12998/wjcc.v12.i18.3644DOI Listing

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