Background: Hypertrophic scar (HTS) is dermal fibroproliferative disorder, which may cause physiological and psychological problems. Currently, the potential mechanism of WuFuYin (WFY) in the treatment of HTS remained to be elucidated.
Aim: To explore the potential mechanism of WFY in treating HTS.
Methods: Active components and corresponding targets were retrieved from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform. HTS-related genes were obtained from the GeneCards, DisGeNET, and National Center for Biotechnology Information. The function of targets was analyzed by performing Gene Ontology and Kyoto Encyclopaedia of Genes and Genome (KEGG) enrichment analysis. A protein + IBM-protein interaction (PPI) network was developed using STRING database and Cytoscape. To confirm the high affinity between compounds and targets, molecular docking was performed.
Results: A total of 65 core genes, which were both related to compounds and HTS, were selected from multiple databases. PPI analysis showed that , , , , glycogen synthase kinase 3 beta (), , , and phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma () were the hub targets and MOL004941, MOL004935, MOL004866, MOL004993, and MOL004989 were the key compounds of WFY against HTS. The results of KEGG enrichment analysis demonstrated that the function of most genes were enriched in the PI3K-Akt pathway. Moreover, by performing molecular docking, we confirmed that and 8-prenylated eriodictyol shared the highest affinity.
Conclusion: The current findings showed that the and cyclin dependent kinase 2 were the potential targets and MOL004941, MOL004989, and MOL004993 were the main compounds of WFY in HTS treatment.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11229930 | PMC |
| http://dx.doi.org/10.12998/wjcc.v12.i18.3505 | DOI Listing |
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