Clinical effect of spleen aminopeptide on improving liver function damage and immune function in children with infant hepatitis syndrome.

Background: Infant hepatitis syndrome (IHS) is a clinical syndrome in infants less than one year of age with generalized skin jaundice, abnormal liver function, and hepatomegaly due to various etiologies such as infection.

Aim: To investigate the effect of IHS patients, after treatment with arsphenamine-based peptides, on patients' liver function damage and immune function.

Methods: Of 110 patients with IHS treated in our hospital from January 2019 to January 2021 were grouped according to the randomized residual grouping method, with 5 cases in each group shed due to transfer, Ultimately, 50 cases remained in each group. The control group was treated with reduced glutathione, and the treatment group was treated with sesquiterpene peptide based on the control group. Observe and compare the differences in indicators after treatment.

Results: The comparison of serum total bilirubin, direct bilirubin, and serum alanine transferase after treatment was significantly different and lower in the treatment group than in the control group ( < 0.05). The comparison of CD4, CD3, CD4/CD8 after treatment was significantly different and higher in the treatment group than in the control group, and the comparison was statistically significant ( < 0.05). The complication of the two groups showed that the rash, cough and sputum, elevated platelets, and gastrointestinal reactions in the treatment group were significantly lower than those in the control group, and the differences were statistically significant by test ( < 0.05).

Conclusion: The comparative study of IHS treated with arsphenamine combined with reduced glutathione is more effective.